Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s11427-021-1929-y http://scihub22266oqcxt.onion/10.1007/s11427-021-1929-y 34047913!8160554!34047913     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+China+Life+Sci 2022 ; 65 (2): 341-361 Nephropedia Template TP {{tp|p=34047913|t=2022. NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry |pdf=|usr=}}{{34047913}} gab.com Text NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry JO: Sci China Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=34047913 #FOAvip Viruses utilize cellular lipids and manipulate host lipid metabolism to ensure their replication and spread. Therefore, the identification of lipids and metabolic pathways that are suitable targets for antiviral development is crucial. Using a library of compounds targeting host lipid metabolic factors and testing them for their ability to block pseudorabies virus (PRV) and vesicular stomatitis virus (VSV) infection, we found that U18666A, a specific inhibitor of Niemann-Pick C1 (NPC1), is highly potent in suppressing the entry of diverse viruses including pseudotyped severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). NPC1 deficiency markedly attenuates viral growth by decreasing cholesterol abundance in the plasma membrane, thereby inhibiting the dynamics of clathrin-coated pits (CCPs), which are indispensable for clathrin-mediated endocytosis. Significantly, exogenous cholesterol can complement the dynamics of CCPs, leading to efficient viral entry and infectivity. Administration of U18666A improves the survival and pathology of PRV- and influenza A virus-infected mice. Thus, our studies demonstrate a unique mechanism by which NPC1 inhibition achieves broad antiviral activity, indicating a potential new therapeutic strategy against SARS-CoV-2, as well as other emerging viruses. Twit Text FOAVip NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry ????Sci China Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=34047913 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34047913 #FOAvip English Wikipedia <ref>{{Cite pmid|34047913}}</ref> NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry #MMPMID34047913 Li G; Su B; Fu P; Bai Y; Ding G; Li D; Wang J; Yang G; Chu B Sci China Life Sci 2022[Feb]; 65 (2): 341-361 PMID34047913show ga Viruses utilize cellular lipids and manipulate host lipid metabolism to ensure their replication and spread. Therefore, the identification of lipids and metabolic pathways that are suitable targets for antiviral development is crucial. Using a library of compounds targeting host lipid metabolic factors and testing them for their ability to block pseudorabies virus (PRV) and vesicular stomatitis virus (VSV) infection, we found that U18666A, a specific inhibitor of Niemann-Pick C1 (NPC1), is highly potent in suppressing the entry of diverse viruses including pseudotyped severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). NPC1 deficiency markedly attenuates viral growth by decreasing cholesterol abundance in the plasma membrane, thereby inhibiting the dynamics of clathrin-coated pits (CCPs), which are indispensable for clathrin-mediated endocytosis. Significantly, exogenous cholesterol can complement the dynamics of CCPs, leading to efficient viral entry and infectivity. Administration of U18666A improves the survival and pathology of PRV- and influenza A virus-infected mice. Thus, our studies demonstrate a unique mechanism by which NPC1 inhibition achieves broad antiviral activity, indicating a potential new therapeutic strategy against SARS-CoV-2, as well as other emerging viruses. |Androstenes/*pharmacology[MESH] |Clathrin/*physiology[MESH] |Coated Pits, Cell-Membrane/*physiology[MESH] |DNA Viruses/*drug effects/physiology[MESH] |Niemann-Pick C1 Protein/antagonists & inhibitors/*physiology[MESH] |RNA Viruses/*drug effects/physiology[MESH]NPC1-regulated dynamic of clathrin-coated pits is essential for viral (epmc).pdf DeepDyve Pubget Overpricing