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10.1038/s41598-021-90701-w http://scihub22266oqcxt.onion/10.1038/s41598-021-90701-w 34045585!8160348!34045585     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34045585&cmd=llinks): Failed to open stream: HTTP request failed! 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Viral fibrotic scoring and drug screen based on MAPK activity uncovers EGFR as a key regulator of COVID-19 fibrosis |pdf=|usr=}}{{34045585}} gab.com Text Viral fibrotic scoring and drug screen based on MAPK activity uncovers EGFR as a key regulator of COVID-19 fibrosis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34045585 #FOAvip Understanding the molecular basis of fibrosis, the lethal complication of COVID-19, is urgent. By the analysis of RNA-sequencing data of SARS-CoV-2-infected cells combined with data mining we identified genes involved in COVID-19 progression. To characterize their implication in the fibrosis development we established a correlation matrix based on the transcriptomic data of patients with idiopathic pulmonary fibrosis. With this method, we have identified a cluster of genes responsible for SARS-CoV-2-fibrosis including its entry receptor ACE2 and epidermal growth factor EGF. Then, we developed Vi-Fi scoring-a novel drug repurposing approach and simultaneously quantified antiviral and antifibrotic activities of the drugs based on their transcriptomic signatures. We revealed the strong dual antifibrotic and antiviral activity of EGFR/ErbB inhibitors. Before the in vitro validation, we have clustered 277 cell lines and revealed distinct COVID-19 transcriptomic signatures of the cells with similar phenotypes that defines their suitability for COVID-19 research. By ERK activity monitoring in living lung cells, we show that the drugs with predicted antifibrotic activity downregulate ERK in the host lung cells. Overall, our study provides novel insights on SARS-CoV-2 dependence on EGFR/ERK signaling and demonstrates the utility of EGFR/ErbB inhibitors for COVID-19 treatment. Twit Text FOAVip Viral fibrotic scoring and drug screen based on MAPK activity uncovers EGFR as a key regulator of COVID-19 fibrosis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34045585 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34045585 #FOAvip English Wikipedia <ref>{{Cite pmid|34045585}}</ref> Viral fibrotic scoring and drug screen based on MAPK activity uncovers EGFR as a key regulator of COVID-19 fibrosis #MMPMID34045585 Vagapova ER; Lebedev TD; Prassolov VS Sci Rep 2021[May]; 11 (1): 11234 PMID34045585show ga Understanding the molecular basis of fibrosis, the lethal complication of COVID-19, is urgent. By the analysis of RNA-sequencing data of SARS-CoV-2-infected cells combined with data mining we identified genes involved in COVID-19 progression. To characterize their implication in the fibrosis development we established a correlation matrix based on the transcriptomic data of patients with idiopathic pulmonary fibrosis. With this method, we have identified a cluster of genes responsible for SARS-CoV-2-fibrosis including its entry receptor ACE2 and epidermal growth factor EGF. Then, we developed Vi-Fi scoring-a novel drug repurposing approach and simultaneously quantified antiviral and antifibrotic activities of the drugs based on their transcriptomic signatures. We revealed the strong dual antifibrotic and antiviral activity of EGFR/ErbB inhibitors. Before the in vitro validation, we have clustered 277 cell lines and revealed distinct COVID-19 transcriptomic signatures of the cells with similar phenotypes that defines their suitability for COVID-19 research. By ERK activity monitoring in living lung cells, we show that the drugs with predicted antifibrotic activity downregulate ERK in the host lung cells. Overall, our study provides novel insights on SARS-CoV-2 dependence on EGFR/ERK signaling and demonstrates the utility of EGFR/ErbB inhibitors for COVID-19 treatment. |Angiotensin-Converting Enzyme 2/genetics/metabolism[MESH] |Antiviral Agents/pharmacology[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/complications/genetics/*metabolism/physiopathology[MESH] |Cell Line, Tumor[MESH] |Cytokines/genetics/*metabolism[MESH] |Disease Progression[MESH] |ErbB Receptors/antagonists & inhibitors/metabolism[MESH] |Fibrosis/complications/genetics/*metabolism/virology[MESH] |Gene Expression Profiling[MESH] |Humans[MESH] |Inflammation/genetics/metabolism[MESH] |MAP Kinase Signaling System/*drug effects[MESH] |Multigene Family[MESH]Viral fibrotic scoring and drug screen based on MAPK activity uncovers(epmc).pdf DeepDyve Pubget Overpricing