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10.1016/j.celrep.2021.109197 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.109197 34043946!8118641!34043946     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2021 ; 35 (9): 109197 Nephropedia Template TP {{tp|p=34043946|t=2021. SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression |pdf=|usr=}}{{34043946}} gab.com Text SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=34043946 #FOAvip Over 950,000 whole-genome sequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been determined for viruses isolated from around the world. These sequences are critical for understanding the spread and evolution of SARS-CoV-2. Using global phylogenomics, we show that mutations frequently occur in the C-terminal end of ORF7a. We isolate one of these mutant viruses from a patient sample and use viral challenge experiments to link this isolate (ORF7a(Delta115)) to a growth defect. ORF7a is implicated in immune modulation, and we show that the C-terminal truncation negates anti-immune activities of the protein, which results in elevated type I interferon response to the viral infection. Collectively, this work indicates that ORF7a mutations occur frequently, and that these changes affect viral mechanisms responsible for suppressing the immune response. Twit Text FOAVip SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=34043946 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34043946 #FOAvip English Wikipedia <ref>{{Cite pmid|34043946}}</ref> SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression #MMPMID34043946 Nemudryi A; Nemudraia A; Wiegand T; Nichols J; Snyder DT; Hedges JF; Cicha C; Lee H; Vanderwood KK; Bimczok D; Jutila MA; Wiedenheft B Cell Rep 2021[Jun]; 35 (9): 109197 PMID34043946show ga Over 950,000 whole-genome sequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been determined for viruses isolated from around the world. These sequences are critical for understanding the spread and evolution of SARS-CoV-2. Using global phylogenomics, we show that mutations frequently occur in the C-terminal end of ORF7a. We isolate one of these mutant viruses from a patient sample and use viral challenge experiments to link this isolate (ORF7a(Delta115)) to a growth defect. ORF7a is implicated in immune modulation, and we show that the C-terminal truncation negates anti-immune activities of the protein, which results in elevated type I interferon response to the viral infection. Collectively, this work indicates that ORF7a mutations occur frequently, and that these changes affect viral mechanisms responsible for suppressing the immune response. |*Immunity[MESH] |Animals[MESH] |COVID-19/*immunology/*virology[MESH] |Chlorocebus aethiops[MESH] |Genome, Viral[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Interferon Type I/immunology[MESH] |Mutation[MESH] |Phylogeny[MESH] |SARS-CoV-2/*genetics/pathogenicity[MESH] |Vero Cells[MESH] |Viral Proteins/*genetics/*immunology[MESH]SARS-CoV-2 genomic surveillance identifies naturally occurring truncat(epmc).pdf DeepDyve Pubget Overpricing