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10.1093/infdis/jiab289 http://scihub22266oqcxt.onion/10.1093/infdis/jiab289 34043806!8243397!34043806     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34043806&cmd=llinks): Failed to open stream: HTTP request failed! 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SARS-CoV-2 Neutralizing Human Antibodies Protect Against Lower Respiratory Tract Disease in a Hamster Model |pdf=|usr=}}{{34043806}} gab.com Text SARS-CoV-2 Neutralizing Human Antibodies Protect Against Lower Respiratory Tract Disease in a Hamster Model JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34043806 #FOAvip Effective clinical intervention strategies for coronavirus disease 2019 (COVID-19) are urgently needed. Although several clinical trials have evaluated use of convalescent plasma containing virus-neutralizing antibodies, levels of neutralizing antibodies are usually not assessed and the effectiveness has not been proven. We show that hamsters treated prophylactically with a 1:2560 titer of human convalescent plasma or a 1:5260 titer of monoclonal antibody were protected against weight loss, had a significant reduction of virus replication in the lungs, and showed reduced pneumonia. Interestingly, this protective effect was lost with a titer of 1:320 of convalescent plasma. These data highlight the importance of screening plasma donors for high levels of neutralizing antibodies. Our data show that prophylactic administration of high levels of neutralizing antibody, either monoclonal or from convalescent plasma, prevent severe SARS-CoV-2 pneumonia in a hamster model, and could be used as an alternative or complementary to other antiviral treatments for COVID-19. Twit Text FOAVip SARS-CoV-2 Neutralizing Human Antibodies Protect Against Lower Respiratory Tract Disease in a Hamster Model ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34043806 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34043806 #FOAvip English Wikipedia <ref>{{Cite pmid|34043806}}</ref> SARS-CoV-2 Neutralizing Human Antibodies Protect Against Lower Respiratory Tract Disease in a Hamster Model #MMPMID34043806 Haagmans BL; Noack D; Okba NMA; Li W; Wang C; Bestebroer T; de Vries R; Herfst S; de Meulder D; Verveer E; van Run P; Lamers MM; Rijnders B; Rokx C; van Kuppeveld F; Grosveld F; Drabek D; Geurts van Kessel C; Koopmans M; Bosch BJ; Kuiken T; Rockx B J Infect Dis 2021[Jun]; 223 (12): 2020-2028 PMID34043806show ga Effective clinical intervention strategies for coronavirus disease 2019 (COVID-19) are urgently needed. Although several clinical trials have evaluated use of convalescent plasma containing virus-neutralizing antibodies, levels of neutralizing antibodies are usually not assessed and the effectiveness has not been proven. We show that hamsters treated prophylactically with a 1:2560 titer of human convalescent plasma or a 1:5260 titer of monoclonal antibody were protected against weight loss, had a significant reduction of virus replication in the lungs, and showed reduced pneumonia. Interestingly, this protective effect was lost with a titer of 1:320 of convalescent plasma. These data highlight the importance of screening plasma donors for high levels of neutralizing antibodies. Our data show that prophylactic administration of high levels of neutralizing antibody, either monoclonal or from convalescent plasma, prevent severe SARS-CoV-2 pneumonia in a hamster model, and could be used as an alternative or complementary to other antiviral treatments for COVID-19. |Animals[MESH] |Antibodies, Monoclonal/administration & dosage/*therapeutic use[MESH] |Antibodies, Neutralizing/administration & dosage/*therapeutic use[MESH] |COVID-19 Serotherapy[MESH] |COVID-19/immunology/*therapy[MESH] |Cricetinae[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Lung/drug effects/*pathology[MESH] |SARS-CoV-2/*immunology[MESH] |Virus Replication/*drug effects[MESH] |Virus Shedding/drug effects[MESH]SARS-CoV-2 Neutralizing Human Antibodies Protect Against Lower Respira(epmc).pdf DeepDyve Pubget Overpricing