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10.1038/s41598-021-90296-2 http://scihub22266oqcxt.onion/10.1038/s41598-021-90296-2 34040048!8155020!34040048     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 11049 Nephropedia Template TP {{tp|p=34040048|t=2021. A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization |pdf=|usr=}}{{34040048}} gab.com Text A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34040048 #FOAvip The SARS-CoV-2 pandemic has challenged researchers at a global scale. The scientific community's massive response has resulted in a flood of experiments, analyses, hypotheses, and publications, especially in the field of drug repurposing. However, many of the proposed therapeutic compounds obtained from SARS-CoV-2 specific assays are not in agreement and thus demonstrate the need for a singular source of COVID-19 related information from which a rational selection of drug repurposing candidates can be made. In this paper, we present the COVID-19 PHARMACOME, a comprehensive drug-target-mechanism graph generated from a compilation of 10 separate disease maps and sources of experimental data focused on SARS-CoV-2/COVID-19 pathophysiology. By applying our systematic approach, we were able to predict the synergistic effect of specific drug pairs, such as Remdesivir and Thioguanosine or Nelfinavir and Raloxifene, on SARS-CoV-2 infection. Experimental validation of our results demonstrate that our graph can be used to not only explore the involved mechanistic pathways, but also to identify novel combinations of drug repurposing candidates. Twit Text FOAVip A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34040048 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34040048 #FOAvip English Wikipedia <ref>{{Cite pmid|34040048}}</ref> A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization #MMPMID34040048 Schultz B; Zaliani A; Ebeling C; Reinshagen J; Bojkova D; Lage-Rupprecht V; Karki R; Lukassen S; Gadiya Y; Ravindra NG; Das S; Baksi S; Domingo-Fernandez D; Lentzen M; Strivens M; Raschka T; Cinatl J; DeLong LN; Gribbon P; Geisslinger G; Ciesek S; van Dijk D; Gardner S; Kodamullil AT; Frohlich H; Peitsch M; Jacobs M; Hoeng J; Eils R; Claussen C; Hofmann-Apitius M Sci Rep 2021[May]; 11 (1): 11049 PMID34040048show ga The SARS-CoV-2 pandemic has challenged researchers at a global scale. The scientific community's massive response has resulted in a flood of experiments, analyses, hypotheses, and publications, especially in the field of drug repurposing. However, many of the proposed therapeutic compounds obtained from SARS-CoV-2 specific assays are not in agreement and thus demonstrate the need for a singular source of COVID-19 related information from which a rational selection of drug repurposing candidates can be made. In this paper, we present the COVID-19 PHARMACOME, a comprehensive drug-target-mechanism graph generated from a compilation of 10 separate disease maps and sources of experimental data focused on SARS-CoV-2/COVID-19 pathophysiology. By applying our systematic approach, we were able to predict the synergistic effect of specific drug pairs, such as Remdesivir and Thioguanosine or Nelfinavir and Raloxifene, on SARS-CoV-2 infection. Experimental validation of our results demonstrate that our graph can be used to not only explore the involved mechanistic pathways, but also to identify novel combinations of drug repurposing candidates. |*COVID-19 Drug Treatment[MESH] |Adenosine Monophosphate/analogs & derivatives/therapeutic use[MESH] |Alanine/analogs & derivatives/therapeutic use[MESH] |Antiviral Agents/*therapeutic use[MESH] |Combined Modality Therapy[MESH] |Computational Biology[MESH] |Drug Repositioning/*methods[MESH] |Drug Synergism[MESH] |Drug Therapy, Combination[MESH] |GTP Phosphohydrolases/therapeutic use[MESH] |Humans[MESH] |Knowledge Bases[MESH] |Nelfinavir/therapeutic use[MESH] |Pandemics[MESH] |Raloxifene Hydrochloride/therapeutic use[MESH]A method for the rational selection of drug repurposing candidates fro(epmc).pdf DeepDyve Pubget Overpricing