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10.1016/j.clinthera.2021.04.010 http://scihub22266oqcxt.onion/10.1016/j.clinthera.2021.04.010 34039479!8141907!34039479     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Ther 2021 ; 43 (6): e163-e172 Nephropedia Template TP {{tp|p=34039479|t=2021. Exploration and Ethical Analysis of Open-label Pediatric Vaccine Trials in a Pandemic |pdf=|usr=}}{{34039479}} gab.com Text Exploration and Ethical Analysis of Open-label Pediatric Vaccine Trials in a Pandemic JO: Clin Ther http://www.kidney.de/pget.php?&tw=1&pmid=34039479 #FOAvip Young children will ultimately need to be vaccinated to stop the spread of coronavirus disease 2019 (COVID-19). Initial studies of vaccine were performed in adults. Randomized controlled trials are the gold standard. In the COVID-19 pandemic, many questions need to be answered about the ethics and feasibility of these trials. Given the harms of the COVID-19 pandemic and the now-known efficacy of the vaccines in adults and teens, the question of whether clinical equipoise exists for a placebo-controlled trial of vaccines in younger children remains. Parents may be reluctant to enroll children in these trials because they want their child to receive the vaccine or because they are worried about vaccines or clinical trials in general. One option for gathering data on tolerability and efficacy in children would be to use a nonrandomized trial to enroll parents willing to vaccinate their children and those who are hesitant. We discuss the advantages and disadvantages of such an open-label trial that could provide guidance for future pandemics. (Clin Ther. Twit Text FOAVip Exploration and Ethical Analysis of Open-label Pediatric Vaccine Trials in a Pandemic ????Clin Ther http://www.kidney.de/pget.php?&tw=1&pmid=34039479 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34039479 #FOAvip English Wikipedia <ref>{{Cite pmid|34039479}}</ref> Exploration and Ethical Analysis of Open-label Pediatric Vaccine Trials in a Pandemic #MMPMID34039479 Wolfe ID; Patel A; Kociolek LK; Fazal A; Jhaveri R; Lantos JD Clin Ther 2021[Jun]; 43 (6): e163-e172 PMID34039479show ga Young children will ultimately need to be vaccinated to stop the spread of coronavirus disease 2019 (COVID-19). Initial studies of vaccine were performed in adults. Randomized controlled trials are the gold standard. In the COVID-19 pandemic, many questions need to be answered about the ethics and feasibility of these trials. Given the harms of the COVID-19 pandemic and the now-known efficacy of the vaccines in adults and teens, the question of whether clinical equipoise exists for a placebo-controlled trial of vaccines in younger children remains. Parents may be reluctant to enroll children in these trials because they want their child to receive the vaccine or because they are worried about vaccines or clinical trials in general. One option for gathering data on tolerability and efficacy in children would be to use a nonrandomized trial to enroll parents willing to vaccinate their children and those who are hesitant. We discuss the advantages and disadvantages of such an open-label trial that could provide guidance for future pandemics. (Clin Ther. |*COVID-19 Vaccines[MESH] |*COVID-19/epidemiology/prevention & control[MESH] |*Clinical Trials as Topic/ethics[MESH] |*Pandemics/prevention & control[MESH] |Child[MESH] |Child, Preschool[MESH] |Ethical Analysis[MESH] |Humans[MESH]Exploration and Ethical Analysis of Open-label Pediatric Vaccine Trial(epmc).pdf DeepDyve Pubget Overpricing