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10.1371/journal.pone.0251426 http://scihub22266oqcxt.onion/10.1371/journal.pone.0251426 34038453!8153447!34038453     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (5): e0251426 Nephropedia Template TP {{tp|p=34038453|t=2021. Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y V1 and 501Y V2 SARS-CoV-2 variants spike protein-an in silico analysis |pdf=|usr=}}{{34038453}} gab.com Text Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y V1 and 501Y V2 SARS-CoV-2 variants spike protein-an in silico analysis JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=34038453 #FOAvip Two SARS-CoV-2 variants of concern showing increased transmissibility relative to the Wuhan virus have recently been identified. Although neither variant appears to cause more severe illness nor increased risk of death, the faster spread of the virus is a major threat. Using computational tools, we found that the new SARS-CoV-2 variants may acquire an increased transmissibility by increasing the propensity of its spike protein to expose the receptor binding domain via proteolysis, perhaps by neutrophil elastase and/or via reduced intramolecular interactions that contribute to the stability of the closed conformation of spike protein. This information leads to the identification of potential treatments to avert the imminent threat of these more transmittable SARS-CoV-2 variants. Twit Text FOAVip Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y V1 and 501Y V2 SARS-CoV-2 variants spike protein-an in silico analysis ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=34038453 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34038453 #FOAvip English Wikipedia <ref>{{Cite pmid|34038453}}</ref> Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y V1 and 501Y V2 SARS-CoV-2 variants spike protein-an in silico analysis #MMPMID34038453 Pokhrel S; Kraemer BR; Lee L; Samardzic K; Mochly-Rosen D PLoS One 2021[]; 16 (5): e0251426 PMID34038453show ga Two SARS-CoV-2 variants of concern showing increased transmissibility relative to the Wuhan virus have recently been identified. Although neither variant appears to cause more severe illness nor increased risk of death, the faster spread of the virus is a major threat. Using computational tools, we found that the new SARS-CoV-2 variants may acquire an increased transmissibility by increasing the propensity of its spike protein to expose the receptor binding domain via proteolysis, perhaps by neutrophil elastase and/or via reduced intramolecular interactions that contribute to the stability of the closed conformation of spike protein. This information leads to the identification of potential treatments to avert the imminent threat of these more transmittable SARS-CoV-2 variants. |Amino Acid Sequence[MESH] |Angiotensin-Converting Enzyme 2/chemistry/metabolism[MESH] |Antibodies, Neutralizing/immunology[MESH] |COVID-19/pathology/virology[MESH] |Humans[MESH] |Molecular Dynamics Simulation[MESH] |Mutation[MESH] |Neutrophils/cytology/metabolism[MESH] |Pancreatic Elastase/*metabolism[MESH] |Protein Binding[MESH] |Protein Stability[MESH] |Protein Structure, Tertiary[MESH] |SARS-CoV-2/isolation & purification/*metabolism/pathogenicity[MESH] |Sequence Alignment[MESH]Increased elastase sensitivity and decreased intramolecular interactio(epmc).pdf DeepDyve Pubget Overpricing