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10.1007/s11538-021-00909-0 http://scihub22266oqcxt.onion/10.1007/s11538-021-00909-0 34037874!8149925!34037874     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34037874&cmd=llinks): Failed to open stream: HTTP request failed! 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Compartmental Model Suggests Importance of Innate Immune Response to COVID-19 Infection in Rhesus Macaques |pdf=|usr=}}{{34037874}} gab.com Text Compartmental Model Suggests Importance of Innate Immune Response to COVID-19 Infection in Rhesus Macaques JO: Bull Math Biol http://www.kidney.de/pget.php?&tw=1&pmid=34037874 #FOAvip The pandemic outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has quickly spread worldwide, creating a serious health crisis. The virus is primarily associated with flu-like symptoms but can also lead to severe pathologies and death. We here present an ordinary differential equation model of the intrahost immune response to SARS-CoV-2 infection, fitted to experimental data gleaned from rhesus macaques. The model is calibrated to data from a nonlethal infection, but the model can replicate behavior from various lethal scenarios as well. We evaluate the sensitivity of the model to biologically relevant parameters governing the strength and efficacy of the immune response. We also simulate the effect of both anti-inflammatory and antiviral drugs on the host immune response and demonstrate the ability of the model to lessen the severity of a formerly lethal infection with the addition of the appropriately calibrated drug. Our model emphasizes the importance of tight control of the innate immune response for host survival and viral clearance. Twit Text FOAVip Compartmental Model Suggests Importance of Innate Immune Response to COVID-19 Infection in Rhesus Macaques ????Bull Math Biol http://www.kidney.de/pget.php?&tw=1&pmid=34037874 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34037874 #FOAvip English Wikipedia <ref>{{Cite pmid|34037874}}</ref> Compartmental Model Suggests Importance of Innate Immune Response to COVID-19 Infection in Rhesus Macaques #MMPMID34037874 Mochan E; Sego TJ; Gaona L; Rial E; Ermentrout GB Bull Math Biol 2021[May]; 83 (7): 79 PMID34037874show ga The pandemic outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has quickly spread worldwide, creating a serious health crisis. The virus is primarily associated with flu-like symptoms but can also lead to severe pathologies and death. We here present an ordinary differential equation model of the intrahost immune response to SARS-CoV-2 infection, fitted to experimental data gleaned from rhesus macaques. The model is calibrated to data from a nonlethal infection, but the model can replicate behavior from various lethal scenarios as well. We evaluate the sensitivity of the model to biologically relevant parameters governing the strength and efficacy of the immune response. We also simulate the effect of both anti-inflammatory and antiviral drugs on the host immune response and demonstrate the ability of the model to lessen the severity of a formerly lethal infection with the addition of the appropriately calibrated drug. Our model emphasizes the importance of tight control of the innate immune response for host survival and viral clearance. |*Immunity, Innate[MESH] |*Models, Immunological[MESH] |*SARS-CoV-2/immunology[MESH] |Adaptive Immunity[MESH] |Aging/immunology[MESH] |Animals[MESH] |Anti-Inflammatory Agents/administration & dosage/pharmacology[MESH] |Antiviral Agents/administration & dosage/pharmacology[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/epidemiology/*immunology[MESH] |Computer Simulation[MESH] |Disease Models, Animal[MESH] |Dose-Response Relationship, Drug[MESH] |Host Microbial Interactions/drug effects/immunology[MESH] |Humans[MESH] |Macaca mulatta/*immunology[MESH] |Mathematical Concepts[MESH] |Pandemics[MESH] |Respiratory System/immunology/virology[MESH]Compartmental Model Suggests Importance of Innate Immune Response to C(epmc).pdf DeepDyve Pubget Overpricing