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10.1039/d1cc01747k

http://scihub22266oqcxt.onion/10.1039/d1cc01747k
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34037640!ä!34037640

suck abstract from ncbi


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pmid34037640      Chem+Commun+(Camb) 2021 ; 57 (49): 6094-6097
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  • Immune evasion of SARS-CoV-2 variants of concern is driven by low affinity to neutralizing antibodies #MMPMID34037640
  • Ferraz MVF; Moreira EG; Coelho DF; Wallau GL; Lins RD
  • Chem Commun (Camb) 2021[Jun]; 57 (49): 6094-6097 PMID34037640show ga
  • SARS-CoV-2 VOC immune evasion is mainly due to lower cross-reactivity from previously elicited class I/II neutralizing antibodies, while increased affinity to hACE2 plays a minor role. The affinity between antibodies and VOCs is impacted by remodeling of the electrostatic surface potential of the Spike RBDs. The P.3 variant is a putative VOC.
  • |Antibodies, Neutralizing/*immunology[MESH]
  • |Antibody Affinity/*genetics/immunology[MESH]
  • |Cross Reactions/genetics[MESH]
  • |Immune Evasion/*genetics[MESH]
  • |Models, Molecular[MESH]
  • |Protein Domains[MESH]
  • |SARS-CoV-2/genetics/*immunology[MESH]
  • |Spike Glycoprotein, Coronavirus/chemistry/genetics/immunology[MESH]


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