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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Med 2021 ; 27 (7): 1230-1238 Nephropedia Template TP
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COVID-19 in Amazonas, Brazil, was driven by the persistence of endemic lineages and P 1 emergence #MMPMID34035535
Naveca FG; Nascimento V; de Souza VC; Corado AL; Nascimento F; Silva G; Costa A; Duarte D; Pessoa K; Mejia M; Brandao MJ; Jesus M; Goncalves L; da Costa CF; Sampaio V; Barros D; Silva M; Mattos T; Pontes G; Abdalla L; Santos JH; Arantes I; Dezordi FZ; Siqueira MM; Wallau GL; Resende PC; Delatorre E; Graf T; Bello G
Nat Med 2021[Jul]; 27 (7): 1230-1238 PMID34035535show ga
The northern state of Amazonas is among the regions in Brazil most heavily affected by the COVID-19 epidemic and has experienced two exponentially growing waves, in early and late 2020. Through a genomic epidemiology study based on 250 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from different Amazonas municipalities sampled between March 2020 and January 2021, we reveal that the first exponential growth phase was driven mostly by the dissemination of lineage B.1.195, which was gradually replaced by lineage B.1.1.28 between May and June 2020. The second wave coincides with the emergence of the variant of concern (VOC) P.1, which evolved from a local B.1.1.28 clade in late November 2020 and replaced the parental lineage in <2 months. Our findings support the conclusion that successive lineage replacements in Amazonas were driven by a complex combination of variable levels of social distancing measures and the emergence of a more transmissible VOC P.1 virus. These data provide insights to understanding the mechanisms underlying the COVID-19 epidemic waves and the risk of dissemination of SARS-CoV-2 VOC P.1 in Brazil and, potentially, worldwide.