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10.1126/sciimmunol.abh1516 http://scihub22266oqcxt.onion/10.1126/sciimmunol.abh1516 34035116!8815705!34035116     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Immunol 2021 ; 6 (59): ä Nephropedia Template TP {{tp|p=34035116|t=2021. Polyclonal expansion of TCR Vbeta 21 3(+) CD4(+) and CD8(+) T cells is a hallmark of Multisystem Inflammatory Syndrome in Children |pdf=|usr=}}{{34035116}} gab.com Text Polyclonal expansion of TCR Vbeta 21 3(+) CD4(+) and CD8(+) T cells is a hallmark of Multisystem Inflammatory Syndrome in Children JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34035116 #FOAvip Multiple Inflammatory Syndrome in Children (MIS-C) is a delayed and severe complication of SARS-CoV-2 infection that strikes previously healthy children. As MIS-C combines clinical features of Kawasaki disease and Toxic Shock Syndrome (TSS), we aimed to compare the immunological profile of pediatric patients with these different conditions. We analyzed blood cytokine expression, and the T cell repertoire and phenotype in 36 MIS-C cases, which were compared to 16 KD, 58 TSS, and 42 COVID-19 cases. We observed an increase of serum inflammatory cytokines (IL-6, IL-10, IL-18, TNF-alpha, IFNgamma, CD25s, MCP1, IL-1RA) in MIS-C, TSS and KD, contrasting with low expression of HLA-DR in monocytes. We detected a specific expansion of activated T cells expressing the Vbeta21.3 T cell receptor beta chain variable region in both CD4 and CD8 subsets in 75% of MIS-C patients and not in any patient with TSS, KD, or acute COVID-19; this correlated with the cytokine storm detected. The T cell repertoire returned to baseline within weeks after MIS-C resolution. Vbeta21.3+ T cells from MIS-C patients expressed high levels of HLA-DR, CD38 and CX3CR1 but had weak responses to SARS-CoV-2 peptides in vitro. Consistently, the T cell expansion was not associated with specific classical HLA alleles. Thus, our data suggested that MIS-C is characterized by a polyclonal Vbeta21.3 T cell expansion not directed against SARS-CoV-2 antigenic peptides, which is not seen in KD, TSS and acute COVID-19. Twit Text FOAVip Polyclonal expansion of TCR Vbeta 21 3(+) CD4(+) and CD8(+) T cells is a hallmark of Multisystem Inflammatory Syndrome in Children ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34035116 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34035116 #FOAvip English Wikipedia <ref>{{Cite pmid|34035116}}</ref> Polyclonal expansion of TCR Vbeta 21 3(+) CD4(+) and CD8(+) T cells is a hallmark of Multisystem Inflammatory Syndrome in Children #MMPMID34035116 Moreews M; Le Gouge K; Khaldi-Plassart S; Pescarmona R; Mathieu AL; Malcus C; Djebali S; Bellomo A; Dauwalder O; Perret M; Villard M; Chopin E; Rouvet I; Vandenesh F; Dupieux C; Pouyau R; Teyssedre S; Guerder M; Louazon T; Moulin-Zinsch A; Duperril M; Patural H; Giovannini-Chami L; Portefaix A; Kassai B; Venet F; Monneret G; Lombard C; Flodrops H; De Guillebon JM; Bajolle F; Launay V; Bastard P; Zhang SY; Dubois V; Thaunat O; Richard JC; Mezidi M; Allatif O; Saker K; Dreux M; Abel L; Casanova JL; Marvel J; Trouillet-Assant S; Klatzmann D; Walzer T; Mariotti-Ferrandiz E; Javouhey E; Belot A Sci Immunol 2021[May]; 6 (59): ä PMID34035116show ga Multiple Inflammatory Syndrome in Children (MIS-C) is a delayed and severe complication of SARS-CoV-2 infection that strikes previously healthy children. As MIS-C combines clinical features of Kawasaki disease and Toxic Shock Syndrome (TSS), we aimed to compare the immunological profile of pediatric patients with these different conditions. We analyzed blood cytokine expression, and the T cell repertoire and phenotype in 36 MIS-C cases, which were compared to 16 KD, 58 TSS, and 42 COVID-19 cases. We observed an increase of serum inflammatory cytokines (IL-6, IL-10, IL-18, TNF-alpha, IFNgamma, CD25s, MCP1, IL-1RA) in MIS-C, TSS and KD, contrasting with low expression of HLA-DR in monocytes. We detected a specific expansion of activated T cells expressing the Vbeta21.3 T cell receptor beta chain variable region in both CD4 and CD8 subsets in 75% of MIS-C patients and not in any patient with TSS, KD, or acute COVID-19; this correlated with the cytokine storm detected. The T cell repertoire returned to baseline within weeks after MIS-C resolution. Vbeta21.3+ T cells from MIS-C patients expressed high levels of HLA-DR, CD38 and CX3CR1 but had weak responses to SARS-CoV-2 peptides in vitro. Consistently, the T cell expansion was not associated with specific classical HLA alleles. Thus, our data suggested that MIS-C is characterized by a polyclonal Vbeta21.3 T cell expansion not directed against SARS-CoV-2 antigenic peptides, which is not seen in KD, TSS and acute COVID-19. |Adult[MESH] |CD4-Positive T-Lymphocytes/*immunology[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |COVID-19/*immunology/*pathology[MESH] |Child[MESH] |Child, Preschool[MESH] |Cytokines/blood[MESH] |HLA-DR Antigens/immunology[MESH] |Humans[MESH] |Lymphocyte Activation/immunology[MESH] |Receptors, Antigen, T-Cell, alpha-beta/*immunology[MESH] |SARS-CoV-2/immunology[MESH]Polyclonal expansion of TCR Vbeta 21 3(+) CD4(+) and CD8(+) T cells is(epmc).pdf DeepDyve Pubget Overpricing