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10.1016/j.healun.2021.04.003

http://scihub22266oqcxt.onion/10.1016/j.healun.2021.04.003
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34034958!8058049!34034958
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suck abstract from ncbi


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pmid34034958      J+Heart+Lung+Transplant 2021 ; 40 (8): 759-762
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  • BNT162b2 vaccination in heart transplant recipients: Clinical experience and antibody response #MMPMID34034958
  • Peled Y; Ram E; Lavee J; Sternik L; Segev A; Wieder-Finesod A; Mandelboim M; Indenbaum V; Levy I; Raanani E; Lustig Y; Rahav G
  • J Heart Lung Transplant 2021[Aug]; 40 (8): 759-762 PMID34034958show ga
  • BACKGROUND: Data on the safety and efficacy of SARS-CoV-2 vaccines in immunocompromised populations are sparse. METHODS: We conducted a prospective study of 77 heart transplant (HT) recipients vaccinated with two doses of BNT162b2 vaccine and monitored for adverse events following both doses, the receptor-binding domain (RBD) IgG response, and neutralizing antibodies. RESULTS: BNT162b2 vaccination was associated with a low rate of adverse events, characterized mostly by pain at the injection site. By a mean 41 days post second dose there were no clinical episodes of rejection, as suggested by a troponin leak or allograft dysfunction. At a mean 21 days following the second dose, IgG anti-RBD antibodies were detectable in 14 (18%) HT recipients. Immune sera neutralized SARS-CoV-2 pseudo-virus in 8 (57%) of those with IgG anti-RBD antibodies. Immunosuppressive regimen containing mycophenolic acid was associated with lower odds of an antibody response (OR?=?0.12, p?=?0.042). CONCLUSIONS: Whether a longer time-frame for observation of an antibody response is required after vaccination in immunosuppressed individuals remains unknown.
  • |*Heart Transplantation[MESH]
  • |Aged[MESH]
  • |Antibody Formation[MESH]
  • |BNT162 Vaccine[MESH]
  • |COVID-19 Vaccines/adverse effects/*immunology[MESH]
  • |COVID-19/*prevention & control[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunosuppression Therapy[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Postoperative Complications/*prevention & control/*virology[MESH]


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