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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Heart+Lung+Transplant 2021 ; 40 (8): 759-762 Nephropedia Template TP
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BNT162b2 vaccination in heart transplant recipients: Clinical experience and antibody response #MMPMID34034958
Peled Y; Ram E; Lavee J; Sternik L; Segev A; Wieder-Finesod A; Mandelboim M; Indenbaum V; Levy I; Raanani E; Lustig Y; Rahav G
J Heart Lung Transplant 2021[Aug]; 40 (8): 759-762 PMID34034958show ga
BACKGROUND: Data on the safety and efficacy of SARS-CoV-2 vaccines in immunocompromised populations are sparse. METHODS: We conducted a prospective study of 77 heart transplant (HT) recipients vaccinated with two doses of BNT162b2 vaccine and monitored for adverse events following both doses, the receptor-binding domain (RBD) IgG response, and neutralizing antibodies. RESULTS: BNT162b2 vaccination was associated with a low rate of adverse events, characterized mostly by pain at the injection site. By a mean 41 days post second dose there were no clinical episodes of rejection, as suggested by a troponin leak or allograft dysfunction. At a mean 21 days following the second dose, IgG anti-RBD antibodies were detectable in 14 (18%) HT recipients. Immune sera neutralized SARS-CoV-2 pseudo-virus in 8 (57%) of those with IgG anti-RBD antibodies. Immunosuppressive regimen containing mycophenolic acid was associated with lower odds of an antibody response (OR?=?0.12, p?=?0.042). CONCLUSIONS: Whether a longer time-frame for observation of an antibody response is required after vaccination in immunosuppressed individuals remains unknown.