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10.1371/journal.pone.0251368 http://scihub22266oqcxt.onion/10.1371/journal.pone.0251368 34033650!8148317!34033650     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34033650&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (5): e0251368 Nephropedia Template TP {{tp|p=34033650|t=2021. SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains |pdf=|usr=}}{{34033650}} gab.com Text SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=34033650 #FOAvip COVID-19 is challenging healthcare preparedness, world economies, and livelihoods. The infection and death rates associated with this pandemic are strikingly variable in different countries. To elucidate this discrepancy, we analyzed 2431 early spread SARS-CoV-2 sequences from GISAID. We estimated continental-wise admixture proportions, assessed haplotype block estimation, and tested for the presence or absence of strains' recombination. Herein, we identified 1010 unique missense mutations and seven different SARS-CoV-2 clusters. In samples from Asia, a small haplotype block was identified, whereas samples from Europe and North America harbored large and different haplotype blocks with nonsynonymous variants. Variant frequency and linkage disequilibrium varied among continents, especially in North America. Recombination between different strains was only observed in North American and European sequences. In addition, we structurally modelled the two most common mutations, Spike_D614G and Nsp12_P314L, which suggested that these linked mutations may enhance viral entry and replication, respectively. Overall, we propose that genomic recombination between different strains may contribute to SARS-CoV-2 virulence and COVID-19 severity and may present additional challenges for current treatment regimens and countermeasures. Furthermore, our study provides a possible explanation for the substantial second wave of COVID-19 presented with higher infection and death rates in many countries. Twit Text FOAVip SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=34033650 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34033650 #FOAvip English Wikipedia <ref>{{Cite pmid|34033650}}</ref> SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains #MMPMID34033650 Haddad D; John SE; Mohammad A; Hammad MM; Hebbar P; Channanath A; Nizam R; Al-Qabandi S; Al Madhoun A; Alshukry A; Ali H; Thanaraj TA; Al-Mulla F PLoS One 2021[]; 16 (5): e0251368 PMID34033650show ga COVID-19 is challenging healthcare preparedness, world economies, and livelihoods. The infection and death rates associated with this pandemic are strikingly variable in different countries. To elucidate this discrepancy, we analyzed 2431 early spread SARS-CoV-2 sequences from GISAID. We estimated continental-wise admixture proportions, assessed haplotype block estimation, and tested for the presence or absence of strains' recombination. Herein, we identified 1010 unique missense mutations and seven different SARS-CoV-2 clusters. In samples from Asia, a small haplotype block was identified, whereas samples from Europe and North America harbored large and different haplotype blocks with nonsynonymous variants. Variant frequency and linkage disequilibrium varied among continents, especially in North America. Recombination between different strains was only observed in North American and European sequences. In addition, we structurally modelled the two most common mutations, Spike_D614G and Nsp12_P314L, which suggested that these linked mutations may enhance viral entry and replication, respectively. Overall, we propose that genomic recombination between different strains may contribute to SARS-CoV-2 virulence and COVID-19 severity and may present additional challenges for current treatment regimens and countermeasures. Furthermore, our study provides a possible explanation for the substantial second wave of COVID-19 presented with higher infection and death rates in many countries. |*Recombination, Genetic[MESH] |COVID-19/pathology/virology[MESH] |Databases, Genetic[MESH] |Genetic Variation[MESH] |Haplotypes[MESH] |Humans[MESH] |Linkage Disequilibrium[MESH] |Molecular Dynamics Simulation[MESH] |Mutation, Missense[MESH] |Principal Component Analysis[MESH] |Protein Structure, Tertiary[MESH] |RNA-Dependent RNA Polymerase/chemistry/genetics/metabolism[MESH] |SARS-CoV-2/genetics/isolation & purification/metabolism/*pathogenicity[MESH] |Severity of Illness Index[MESH] |Spike Glycoprotein, Coronavirus/chemistry/*genetics/metabolism[MESH]SARS-CoV-2: Possible recombination and emergence of potentially more v(epmc).pdf DeepDyve Pubget Overpricing