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10.1001/jamanetworkopen.2021.11398 http://scihub22266oqcxt.onion/10.1001/jamanetworkopen.2021.11398 34032853!8150664!34032853     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JAMA+Netw+Open 2021 ; 4 (5): e2111398 Nephropedia Template TP {{tp|p=34032853|t=2021. Association of Circulating Sex Hormones With Inflammation and Disease Severity in Patients With COVID-19 |pdf=|usr=}}{{34032853}} gab.com Text Association of Circulating Sex Hormones With Inflammation and Disease Severity in Patients With COVID-19 JO: JAMA Netw Open http://www.kidney.de/pget.php?&tw=1&pmid=34032853 #FOAvip IMPORTANCE: Male sex is a risk factor for developing severe COVID-19 illness. It is not known whether sex hormones contribute to this predisposition. OBJECTIVE: To investigate the association of concentrations of serum testosterone, estradiol, and insulinlike growth factor 1 (IGF-1, concentrations of which are regulated by sex hormone signaling) with COVID-19 severity. DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort study was conducted using serum samples collected from consecutive patients who presented from March through May 2020 to the Barnes Jewish Hospital in St Louis, Missouri, with COVID-19 (diagnosed using nasopharyngeal swabs). EXPOSURES: Testosterone, estradiol, and IGF-1 concentrations were measured at the time of presentation (ie, day 0) and at days 3, 7, 14, and 28 after admission (if the patient remained hospitalized). MAIN OUTCOMES AND MEASURES: Baseline hormone concentrations were compared among patients who had severe COVID-19 vs those with milder COVID-19 illness. RNA sequencing was performed on circulating mononuclear cells to understand the mechanistic association of altered circulating hormone concentrations with cellular signaling pathways. RESULTS: Among 152 patients (90 [59.2%] men; 62 [40.8%] women; mean [SD] age, 63 [16] years), 143 patients (94.1%) were hospitalized. Among 66 men with severe COVID-19, median [interquartile range] testosterone concentrations were lower at day 0 (53 [18 to 114] ng/dL vs 151 [95 to 217] ng/dL; P = .01) and day 3 (19 [6 to 68] ng/dL vs 111 [49 to 274] ng/dL; P = .006) compared with 24 men with milder disease. Testosterone concentrations were inversely associated with concentrations of interleukin 6 (beta = -0.43; 95% CI, -0.52 to -0.17; P < .001), C-reactive protein (beta = -0.38; 95% CI, -0.78 to -0.16; P = .004), interleukin 1 receptor antagonist (beta = -0.29; 95% CI, -0.64 to -0.06; P = .02), hepatocyte growth factor (beta = -0.46; 95% CI, -0.69 to -0.25; P < .001), and interferon gamma-inducible protein 10 (beta = -0.32; 95% CI, -0.62 to -0.10; P = .007). Estradiol and IGF-1 concentrations were not associated with COVID-19 severity in men. Testosterone, estradiol, and IGF-1 concentrations were similar in women with and without severe COVID-19. Gene set enrichment analysis revealed upregulated hormone signaling pathways in CD14+CD16- (ie, classical) monocytes and CD14-CD16+ (ie, nonclassical) monocytes in male patients with COVID-19 who needed intensive care unit treatment vs those who did not. CONCLUSIONS AND RELEVANCE: In this single-center cohort study of patients with COVID-19, lower testosterone concentrations during hospitalization were associated with increased disease severity and inflammation in men. Hormone signaling pathways in monocytes did not parallel serum hormone concentrations, and further investigation is required to understand their pathophysiologic association with COVID-19. Twit Text FOAVip Association of Circulating Sex Hormones With Inflammation and Disease Severity in Patients With COVID-19 ????JAMA Netw Open http://www.kidney.de/pget.php?&tw=1&pmid=34032853 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34032853 #FOAvip English Wikipedia <ref>{{Cite pmid|34032853}}</ref> Association of Circulating Sex Hormones With Inflammation and Disease Severity in Patients With COVID-19 #MMPMID34032853 Dhindsa S; Zhang N; McPhaul MJ; Wu Z; Ghoshal AK; Erlich EC; Mani K; Randolph GJ; Edwards JR; Mudd PA; Diwan A JAMA Netw Open 2021[May]; 4 (5): e2111398 PMID34032853show ga IMPORTANCE: Male sex is a risk factor for developing severe COVID-19 illness. It is not known whether sex hormones contribute to this predisposition. OBJECTIVE: To investigate the association of concentrations of serum testosterone, estradiol, and insulinlike growth factor 1 (IGF-1, concentrations of which are regulated by sex hormone signaling) with COVID-19 severity. DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort study was conducted using serum samples collected from consecutive patients who presented from March through May 2020 to the Barnes Jewish Hospital in St Louis, Missouri, with COVID-19 (diagnosed using nasopharyngeal swabs). EXPOSURES: Testosterone, estradiol, and IGF-1 concentrations were measured at the time of presentation (ie, day 0) and at days 3, 7, 14, and 28 after admission (if the patient remained hospitalized). MAIN OUTCOMES AND MEASURES: Baseline hormone concentrations were compared among patients who had severe COVID-19 vs those with milder COVID-19 illness. RNA sequencing was performed on circulating mononuclear cells to understand the mechanistic association of altered circulating hormone concentrations with cellular signaling pathways. RESULTS: Among 152 patients (90 [59.2%] men; 62 [40.8%] women; mean [SD] age, 63 [16] years), 143 patients (94.1%) were hospitalized. Among 66 men with severe COVID-19, median [interquartile range] testosterone concentrations were lower at day 0 (53 [18 to 114] ng/dL vs 151 [95 to 217] ng/dL; P = .01) and day 3 (19 [6 to 68] ng/dL vs 111 [49 to 274] ng/dL; P = .006) compared with 24 men with milder disease. Testosterone concentrations were inversely associated with concentrations of interleukin 6 (beta = -0.43; 95% CI, -0.52 to -0.17; P < .001), C-reactive protein (beta = -0.38; 95% CI, -0.78 to -0.16; P = .004), interleukin 1 receptor antagonist (beta = -0.29; 95% CI, -0.64 to -0.06; P = .02), hepatocyte growth factor (beta = -0.46; 95% CI, -0.69 to -0.25; P < .001), and interferon gamma-inducible protein 10 (beta = -0.32; 95% CI, -0.62 to -0.10; P = .007). Estradiol and IGF-1 concentrations were not associated with COVID-19 severity in men. Testosterone, estradiol, and IGF-1 concentrations were similar in women with and without severe COVID-19. Gene set enrichment analysis revealed upregulated hormone signaling pathways in CD14+CD16- (ie, classical) monocytes and CD14-CD16+ (ie, nonclassical) monocytes in male patients with COVID-19 who needed intensive care unit treatment vs those who did not. CONCLUSIONS AND RELEVANCE: In this single-center cohort study of patients with COVID-19, lower testosterone concentrations during hospitalization were associated with increased disease severity and inflammation in men. Hormone signaling pathways in monocytes did not parallel serum hormone concentrations, and further investigation is required to understand their pathophysiologic association with COVID-19. |*Hospitalization[MESH] |*Severity of Illness Index[MESH] |Aged[MESH] |COVID-19/*blood/complications/pathology[MESH] |Estradiol/blood[MESH] |Female[MESH] |Gonadal Steroid Hormones/blood[MESH] |Hospitals[MESH] |Humans[MESH] |Inflammation/blood/*etiology[MESH] |Insulin-Like Growth Factor I/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Missouri[MESH] |SARS-CoV-2[MESH] |Sex Factors[MESH]Association of Circulating Sex Hormones With Inflammation and Disease (epmc).pdf DeepDyve Pubget Overpricing