Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1172/JCI149633 http://scihub22266oqcxt.onion/10.1172/JCI149633 34032635!8279585!34032635     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2021 ; 131 (14): ä Nephropedia Template TP {{tp|p=34032635|t=2021. Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier |pdf=|usr=}}{{34032635}} gab.com Text Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=34032635 #FOAvip BACKGROUNDWeeks after SARS-CoV-2 infection or exposure, some children develop a severe, life-threatening illness called multisystem inflammatory syndrome in children (MIS-C). Gastrointestinal (GI) symptoms are common in patients with MIS-C, and a severe hyperinflammatory response ensues with potential for cardiac complications. The cause of MIS-C has not been identified to date.METHODSHere, we analyzed biospecimens from 100 children: 19 with MIS-C, 26 with acute COVID-19, and 55 controls. Stools were assessed for SARS-CoV-2 by reverse transcription PCR (RT-PCR), and plasma was examined for markers of breakdown of mucosal barrier integrity, including zonulin. Ultrasensitive antigen detection was used to probe for SARS-CoV-2 antigenemia in plasma, and immune responses were characterized. As a proof of concept, we treated a patient with MIS-C with larazotide, a zonulin antagonist, and monitored the effect on antigenemia and the patient's clinical response.RESULTSWe showed that in children with MIS-C, a prolonged presence of SARS-CoV-2 in the GI tract led to the release of zonulin, a biomarker of intestinal permeability, with subsequent trafficking of SARS-CoV-2 antigens into the bloodstream, leading to hyperinflammation. The patient with MIS-C treated with larazotide had a coinciding decrease in plasma SARS-CoV-2 spike antigen levels and inflammatory markers and a resultant clinical improvement above that achieved with currently available treatments.CONCLUSIONThese mechanistic data on MIS-C pathogenesis provide insight into targets for diagnosing, treating, and preventing MIS-C, which are urgently needed for this increasingly common severe COVID-19-related disease in children. Twit Text FOAVip Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=34032635 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34032635 #FOAvip English Wikipedia <ref>{{Cite pmid|34032635}}</ref> Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier #MMPMID34032635 Yonker LM; Gilboa T; Ogata AF; Senussi Y; Lazarovits R; Boribong BP; Bartsch YC; Loiselle M; Rivas MN; Porritt RA; Lima R; Davis JP; Farkas EJ; Burns MD; Young N; Mahajan VS; Hajizadeh S; Lopez XIH; Kreuzer J; Morris R; Martinez EE; Han I; Griswold K Jr; Barry NC; Thompson DB; Church G; Edlow AG; Haas W; Pillai S; Arditi M; Alter G; Walt DR; Fasano A J Clin Invest 2021[Jul]; 131 (14): ä PMID34032635show ga BACKGROUNDWeeks after SARS-CoV-2 infection or exposure, some children develop a severe, life-threatening illness called multisystem inflammatory syndrome in children (MIS-C). Gastrointestinal (GI) symptoms are common in patients with MIS-C, and a severe hyperinflammatory response ensues with potential for cardiac complications. The cause of MIS-C has not been identified to date.METHODSHere, we analyzed biospecimens from 100 children: 19 with MIS-C, 26 with acute COVID-19, and 55 controls. Stools were assessed for SARS-CoV-2 by reverse transcription PCR (RT-PCR), and plasma was examined for markers of breakdown of mucosal barrier integrity, including zonulin. Ultrasensitive antigen detection was used to probe for SARS-CoV-2 antigenemia in plasma, and immune responses were characterized. As a proof of concept, we treated a patient with MIS-C with larazotide, a zonulin antagonist, and monitored the effect on antigenemia and the patient's clinical response.RESULTSWe showed that in children with MIS-C, a prolonged presence of SARS-CoV-2 in the GI tract led to the release of zonulin, a biomarker of intestinal permeability, with subsequent trafficking of SARS-CoV-2 antigens into the bloodstream, leading to hyperinflammation. The patient with MIS-C treated with larazotide had a coinciding decrease in plasma SARS-CoV-2 spike antigen levels and inflammatory markers and a resultant clinical improvement above that achieved with currently available treatments.CONCLUSIONThese mechanistic data on MIS-C pathogenesis provide insight into targets for diagnosing, treating, and preventing MIS-C, which are urgently needed for this increasingly common severe COVID-19-related disease in children. |*SARS-CoV-2/immunology/pathogenicity[MESH] |Adolescent[MESH] |Antigens, Viral/blood[MESH] |Biomarkers/blood[MESH] |COVID-19/*etiology/*physiopathology/virology[MESH] |Case-Control Studies[MESH] |Child[MESH] |Child, Preschool[MESH] |Female[MESH] |Haptoglobins/antagonists & inhibitors/*physiology[MESH] |Humans[MESH] |Infant[MESH] |Infant, Newborn[MESH] |Intestinal Mucosa/drug effects/*physiopathology/virology[MESH] |Male[MESH] |Oligopeptides/pharmacology[MESH] |Permeability/drug effects[MESH] |Proof of Concept Study[MESH] |Protein Precursors/antagonists & inhibitors/blood/*physiology[MESH] |Spike Glycoprotein, Coronavirus/blood/immunology[MESH] |Systemic Inflammatory Response Syndrome/*etiology/*physiopathology/virology[MESH]Multisystem inflammatory syndrome in children is driven by zonulin-dep(epmc).pdf DeepDyve Pubget Overpricing