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10.1007/5584_2021_640 http://scihub22266oqcxt.onion/10.1007/5584_2021_640 34031864!ä!34031864 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Exp+Med+Biol 2021 ; 1347 (ä): 197-219 Nephropedia Template TP {{tp|p=34031864|t=2021. Eosinophils as Major Player in Type 2 Inflammation: Autoimmunity and Beyond |pdf=|usr=}}{{34031864}} gab.com Text Eosinophils as Major Player in Type 2 Inflammation: Autoimmunity and Beyond JO: Adv Exp Med Biol http://www.kidney.de/pget.php?&tw=1&pmid=34031864 #FOAvip Eosinophils are a subset of differentiated granulocytes which circulate in peripheral blood and home in several body tissues. Along with their traditional relevance in helminth immunity and allergy, eosinophils have been progressively attributed important roles in a number of homeostatic and pathologic situations. This review aims at summarizing available evidence about eosinophils functions in homeostasis, infections, allergic and autoimmune disorders, and solid and hematological cancers.Their structural and biological features have been described, along with their physiological behavior. This includes their chemokines, cytokines, granular contents, and extracellular traps. Besides, pathogenic- and eosinophilic-mediated disorders have also been addressed, with the aim of highlighting their role in Th2-driven inflammation. In allergy, eosinophils are implicated in the pathogenesis of atopic dermatitis, allergic rhinitis, and asthma. They are also fundamentally involved in autoimmune disorders such as eosinophilic esophagitis, eosinophilic gastroenteritis, acute and chronic eosinophilic pneumonia, and eosinophilic granulomatosis with polyangiitis. In infections, eosinophils are involved in protection not only from parasites but also from fungi, viruses, and bacteria. In solid cancers, local eosinophilic infiltration is variably associated with an improved or worsened prognosis, depending on the histotype. In hematologic neoplasms, eosinophilia can be the consequence of a dysregulated cytokine production or the result of mutations affecting the myeloid lineage.Recent experimental evidence was thoroughly reviewed, with findings which elicit a complex role for eosinophils, in a tight balance between host defense and tissue damage. Eventually, emerging evidence about eosinophils in COVID-19 infection was also discussed. Twit Text FOAVip Eosinophils as Major Player in Type 2 Inflammation: Autoimmunity and Beyond ????Adv Exp Med Biol http://www.kidney.de/pget.php?&tw=1&pmid=34031864 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34031864 #FOAvip English Wikipedia <ref>{{Cite pmid|34031864}}</ref> Eosinophils as Major Player in Type 2 Inflammation: Autoimmunity and Beyond #MMPMID34031864 Folci M; Ramponi G; Arcari I; Zumbo A; Brunetta E Adv Exp Med Biol 2021[]; 1347 (ä): 197-219 PMID34031864show ga Eosinophils are a subset of differentiated granulocytes which circulate in peripheral blood and home in several body tissues. Along with their traditional relevance in helminth immunity and allergy, eosinophils have been progressively attributed important roles in a number of homeostatic and pathologic situations. This review aims at summarizing available evidence about eosinophils functions in homeostasis, infections, allergic and autoimmune disorders, and solid and hematological cancers.Their structural and biological features have been described, along with their physiological behavior. This includes their chemokines, cytokines, granular contents, and extracellular traps. Besides, pathogenic- and eosinophilic-mediated disorders have also been addressed, with the aim of highlighting their role in Th2-driven inflammation. In allergy, eosinophils are implicated in the pathogenesis of atopic dermatitis, allergic rhinitis, and asthma. They are also fundamentally involved in autoimmune disorders such as eosinophilic esophagitis, eosinophilic gastroenteritis, acute and chronic eosinophilic pneumonia, and eosinophilic granulomatosis with polyangiitis. In infections, eosinophils are involved in protection not only from parasites but also from fungi, viruses, and bacteria. In solid cancers, local eosinophilic infiltration is variably associated with an improved or worsened prognosis, depending on the histotype. In hematologic neoplasms, eosinophilia can be the consequence of a dysregulated cytokine production or the result of mutations affecting the myeloid lineage.Recent experimental evidence was thoroughly reviewed, with findings which elicit a complex role for eosinophils, in a tight balance between host defense and tissue damage. Eventually, emerging evidence about eosinophils in COVID-19 infection was also discussed. |*COVID-19[MESH] |*Churg-Strauss Syndrome[MESH] |*Granulomatosis with Polyangiitis[MESH] |*Rhinitis, Allergic[MESH] |Autoimmunity[MESH] |Eosinophils[MESH] |Humans[MESH] |Inflammation[MESH]Eosinophils as Major Player in Type 2 Inflammation: Autoimmunity and B(epmc).pdf DeepDyve Pubget Overpricing