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10.1038/s41557-021-00707-0 http://scihub22266oqcxt.onion/10.1038/s41557-021-00707-0 34031561!8249329!34031561     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34031561.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Chem 2021 ; 13 (7): 651-659 Nephropedia Template TP {{tp|p=34031561|t=2021. SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome |pdf=|usr=}}{{34031561}} gab.com Text SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome JO: Nat Chem http://www.kidney.de/pget.php?&tw=1&pmid=34031561 #FOAvip SARS-CoV-2 has intricate mechanisms for initiating infection, immune evasion/suppression and replication that depend on the structure and dynamics of its constituent proteins. Many protein structures have been solved, but far less is known about their relevant conformational changes. To address this challenge, over a million citizen scientists banded together through the Folding@home distributed computing project to create the first exascale computer and simulate 0.1 seconds of the viral proteome. Our adaptive sampling simulations predict dramatic opening of the apo spike complex, far beyond that seen experimentally, explaining and predicting the existence of 'cryptic' epitopes. Different spike variants modulate the probabilities of open versus closed structures, balancing receptor binding and immune evasion. We also discover dramatic conformational changes across the proteome, which reveal over 50 'cryptic' pockets that expand targeting options for the design of antivirals. All data and models are freely available online, providing a quantitative structural atlas. Twit Text FOAVip SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome ????Nat Chem http://www.kidney.de/pget.php?&tw=1&pmid=34031561 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34031561 #FOAvip English Wikipedia <ref>{{Cite pmid|34031561}}</ref> SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome #MMPMID34031561 Zimmerman MI; Porter JR; Ward MD; Singh S; Vithani N; Meller A; Mallimadugula UL; Kuhn CE; Borowsky JH; Wiewiora RP; Hurley MFD; Harbison AM; Fogarty CA; Coffland JE; Fadda E; Voelz VA; Chodera JD; Bowman GR Nat Chem 2021[Jul]; 13 (7): 651-659 PMID34031561show ga SARS-CoV-2 has intricate mechanisms for initiating infection, immune evasion/suppression and replication that depend on the structure and dynamics of its constituent proteins. Many protein structures have been solved, but far less is known about their relevant conformational changes. To address this challenge, over a million citizen scientists banded together through the Folding@home distributed computing project to create the first exascale computer and simulate 0.1 seconds of the viral proteome. Our adaptive sampling simulations predict dramatic opening of the apo spike complex, far beyond that seen experimentally, explaining and predicting the existence of 'cryptic' epitopes. Different spike variants modulate the probabilities of open versus closed structures, balancing receptor binding and immune evasion. We also discover dramatic conformational changes across the proteome, which reveal over 50 'cryptic' pockets that expand targeting options for the design of antivirals. All data and models are freely available online, providing a quantitative structural atlas. |Binding Sites[MESH] |COVID-19/transmission/*virology[MESH] |Computer Simulation[MESH] |Humans[MESH] |Molecular Dynamics Simulation[MESH] |Protein Binding[MESH] |Protein Conformation[MESH] |Proteome[MESH] |SARS-CoV-2/*metabolism[MESH]SARS-CoV-2 simulations go exascale to predict dramatic spike opening a(epmc).pdf DeepDyve Pubget Overpricing