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10.1038/s41540-021-00181-x http://scihub22266oqcxt.onion/10.1038/s41540-021-00181-x 34031419!8144203!34031419     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34031419.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       NPJ+Syst+Biol+Appl 2021 ; 7 (1): 21 Nephropedia Template TP {{tp|p=34031419|t=2021. Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection |pdf=|usr=}}{{34031419}} gab.com Text Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection JO: NPJ Syst Biol Appl http://www.kidney.de/pget.php?&tw=1&pmid=34031419 #FOAvip COVID-19 is an infection caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2), which has caused a global outbreak. Current research efforts are focused on the understanding of the molecular mechanisms involved in SARS-CoV-2 infection in order to propose drug-based therapeutic options. Transcriptional changes due to epigenetic regulation are key host cell responses to viral infection and have been studied in SARS-CoV and MERS-CoV; however, such changes are not fully described for SARS-CoV-2. In this study, we analyzed multiple transcriptomes obtained from cell lines infected with MERS-CoV, SARS-CoV, and SARS-CoV-2, and from COVID-19 patient-derived samples. Using integrative analyses of gene co-expression networks and de-novo pathway enrichment, we characterize different gene modules and protein pathways enriched with Transcription Factors or Epifactors relevant for SARS-CoV-2 infection. We identified EP300, MOV10, RELA, and TRIM25 as top candidates, and more than 60 additional proteins involved in the epigenetic response during viral infection that has therapeutic potential. Our results show that targeting the epigenetic machinery could be a feasible alternative to treat COVID-19. Twit Text FOAVip Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection ????NPJ Syst Biol Appl http://www.kidney.de/pget.php?&tw=1&pmid=34031419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34031419 #FOAvip English Wikipedia <ref>{{Cite pmid|34031419}}</ref> Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection #MMPMID34031419 Salgado-Albarran M; Navarro-Delgado EI; Del Moral-Morales A; Alcaraz N; Baumbach J; Gonzalez-Barrios R; Soto-Reyes E NPJ Syst Biol Appl 2021[May]; 7 (1): 21 PMID34031419show ga COVID-19 is an infection caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2), which has caused a global outbreak. Current research efforts are focused on the understanding of the molecular mechanisms involved in SARS-CoV-2 infection in order to propose drug-based therapeutic options. Transcriptional changes due to epigenetic regulation are key host cell responses to viral infection and have been studied in SARS-CoV and MERS-CoV; however, such changes are not fully described for SARS-CoV-2. In this study, we analyzed multiple transcriptomes obtained from cell lines infected with MERS-CoV, SARS-CoV, and SARS-CoV-2, and from COVID-19 patient-derived samples. Using integrative analyses of gene co-expression networks and de-novo pathway enrichment, we characterize different gene modules and protein pathways enriched with Transcription Factors or Epifactors relevant for SARS-CoV-2 infection. We identified EP300, MOV10, RELA, and TRIM25 as top candidates, and more than 60 additional proteins involved in the epigenetic response during viral infection that has therapeutic potential. Our results show that targeting the epigenetic machinery could be a feasible alternative to treat COVID-19. |COVID-19/*genetics/virology[MESH] |Epigenesis, Genetic/*genetics[MESH] |Gene Expression Profiling[MESH] |Humans[MESH] |Middle East Respiratory Syndrome Coronavirus/genetics/pathogenicity[MESH] |SARS-CoV-2/*genetics/pathogenicity[MESH] |Severe acute respiratory syndrome-related coronavirus/genetics/pathogenicity[MESH] |Signal Transduction/genetics[MESH]Comparative transcriptome analysis reveals key epigenetic targets in S(epmc).pdf DeepDyve Pubget Overpricing