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10.1186/s12920-021-00970-7 http://scihub22266oqcxt.onion/10.1186/s12920-021-00970-7 34030677!8142073!34030677     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34030677&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       BMC+Med+Genomics 2021 ; 14 (1): 138 Nephropedia Template TP {{tp|p=34030677|t=2021. Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease |pdf=|usr=}}{{34030677}} gab.com Text Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease JO: BMC Med Genomics http://www.kidney.de/pget.php?&tw=1&pmid=34030677 #FOAvip BACKGROUND: Older aged adults and those with pre-existing conditions are at highest risk for severe COVID-19 associated outcomes. METHODS: Using a large dataset of genome-wide RNA-seq profiles derived from human dermal fibroblasts (GSE113957) we investigated whether age affects the expression of pattern recognition receptor (PRR) genes and ACE2, the receptor for SARS-CoV-2. RESULTS: Extremes of age are associated with increased expression of selected PRR genes, ACE2 and four genes that encode proteins that have been shown to interact with SAR2-CoV-2 proteins. CONCLUSIONS: Assessment of PRR expression might provide a strategy for stratifying the risk of severe COVID-19 disease at both the individual and population levels. Twit Text FOAVip Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease ????BMC Med Genomics http://www.kidney.de/pget.php?&tw=1&pmid=34030677 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34030677 #FOAvip English Wikipedia <ref>{{Cite pmid|34030677}}</ref> Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease #MMPMID34030677 Bickler SW; Cauvi DM; Fisch KM; Prieto JM; Sykes AG; Thangarajah H; Lazar DA; Ignacio RC; Gerstmann DR; Ryan AF; Bickler PE; De Maio A BMC Med Genomics 2021[May]; 14 (1): 138 PMID34030677show ga BACKGROUND: Older aged adults and those with pre-existing conditions are at highest risk for severe COVID-19 associated outcomes. METHODS: Using a large dataset of genome-wide RNA-seq profiles derived from human dermal fibroblasts (GSE113957) we investigated whether age affects the expression of pattern recognition receptor (PRR) genes and ACE2, the receptor for SARS-CoV-2. RESULTS: Extremes of age are associated with increased expression of selected PRR genes, ACE2 and four genes that encode proteins that have been shown to interact with SAR2-CoV-2 proteins. CONCLUSIONS: Assessment of PRR expression might provide a strategy for stratifying the risk of severe COVID-19 disease at both the individual and population levels. |*Gene Expression Regulation[MESH] |Adolescent[MESH] |Adult[MESH] |Age Factors[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/*genetics/*virology[MESH] |Child[MESH] |Dermis/pathology[MESH] |Fibroblasts/metabolism[MESH] |Gene Expression Profiling[MESH] |Humans[MESH] |Middle Aged[MESH] |Peptidyl-Dipeptidase A/*genetics[MESH] |RNA-Seq[MESH] |Receptors, Pattern Recognition/*genetics[MESH] |Receptors, Virus/*genetics/metabolism[MESH] |SARS-CoV-2/*metabolism[MESH]Extremes of age are associated with differences in the expression of s(epmc).pdf DeepDyve Pubget Overpricing