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10.1080/09546634.2021.1927947

http://scihub22266oqcxt.onion/10.1080/09546634.2021.1927947
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suck abstract from ncbi


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pmid34030547      J+Dermatolog+Treat 2022 ; 33 (4): 2137-2144
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  • The impact of COVID-19 pandemic on psoriasis patients, and their immunosuppressive treatment: a cross-sectional multicenter study from Turkey #MMPMID34030547
  • Kartal SP; Celik G; Yilmaz O; Oksum Solak E; Demirbag Gul B; Ustunbas TK; Gonulal M; Baysak S; Yuksel EI; Unlu B; Guven M; Bozdag A; Cinar G; Kartal S; Borlu M; Ozden MG; Engin B; Serdaroglu S; Balci DD; Dogan B; Cicek D; Yazici AC; Aytekin S; Sendur N; Saricaoglu H; Kacar NG; Dogramaci AC; Donmez L; Alpsoy E
  • J Dermatolog Treat 2022[Jun]; 33 (4): 2137-2144 PMID34030547show ga
  • BACKGROUND: Immunosuppressive therapy has been a great concern during the pandemic. This study aimed to evaluate the pandemic's impact on psoriasis patients treated with immunosuppressive drugs. MATERIAL AND METHODS: The multicenter study was conducted in 14 tertiary dermatology centers. Demographic data, treatment status, disease course, and cases of COVID-19 were evaluated in patients with psoriasis using the immunosuppressive treatment. RESULTS: Of 1827 patients included, the drug adherence rate was 68.2%. Those receiving anti-interleukin (anti-IL) drugs were more likely to continue treatment than patients receiving conventional drugs (OR = 1.50, 95% CI, 1.181-1.895, p = .001). Disease worsening rate was 24.2% and drug dose reduction increased this rate 3.26 and drug withdrawal 8.71 times. Receiving anti-TNF or anti-IL drugs was associated with less disease worsening compared to conventional drugs (p = .038, p = .032; respectively). Drug withdrawal causes were 'unable to come' (39.6%), 'COVID concern' (25.3%), and 'physician's and patient's co-decision' (17.4%). Four patients had COVID-19 infection with mild symptoms. The incidence was 0.0022% while it was 0.0025% in the general population. CONCLUSION: Our study shows that psoriasis patients using systemic immunosuppressive do not have a higher, but even lower COVID-19 risk than the general population, and treatment compliance with biological drugs is higher.
  • |*Biological Products/adverse effects[MESH]
  • |*COVID-19[MESH]
  • |*Psoriasis/chemically induced/drug therapy[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Humans[MESH]
  • |Immunosuppressive Agents/adverse effects[MESH]
  • |Pandemics[MESH]
  • |Tumor Necrosis Factor Inhibitors[MESH]


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