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10.1038/s41586-021-03647-4 http://scihub22266oqcxt.onion/10.1038/s41586-021-03647-4 34030176!ä!34030176 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2021 ; 595 (7867): 421-425 Nephropedia Template TP {{tp|p=34030176|t=2021. SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans |pdf=|usr=}}{{34030176}} gab.com Text SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=34030176 #FOAvip Long-lived bone marrow plasma cells (BMPCs) are a persistent and essential source of protective antibodies(1-7). Individuals who have recovered from COVID-19 have a substantially lower risk of reinfection with SARS-CoV-2(8-10). Nonetheless, it has been reported that levels of anti-SARS-CoV-2 serum antibodies decrease rapidly in the first few months after infection, raising concerns that long-lived BMPCs may not be generated and humoral immunity against SARS-CoV-2 may be short-lived(11-13). Here we show that in convalescent individuals who had experienced mild SARS-CoV-2 infections (n = 77), levels of serum anti-SARS-CoV-2 spike protein (S) antibodies declined rapidly in the first 4 months after infection and then more gradually over the following 7 months, remaining detectable at least 11 months after infection. Anti-S antibody titres correlated with the frequency of S-specific plasma cells in bone marrow aspirates from 18 individuals who had recovered from COVID-19 at 7 to 8 months after infection. S-specific BMPCs were not detected in aspirates from 11 healthy individuals with no history of SARS-CoV-2 infection. We show that S-binding BMPCs are quiescent, which suggests that they are part of a stable compartment. Consistently, circulating resting memory B cells directed against SARS-CoV-2 S were detected in the convalescent individuals. Overall, our results indicate that mild infection with SARS-CoV-2 induces robust antigen-specific, long-lived humoral immune memory in humans. Twit Text FOAVip SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=34030176 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34030176 #FOAvip English Wikipedia <ref>{{Cite pmid|34030176}}</ref> SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans #MMPMID34030176 Turner JS; Kim W; Kalaidina E; Goss CW; Rauseo AM; Schmitz AJ; Hansen L; Haile A; Klebert MK; Pusic I; O'Halloran JA; Presti RM; Ellebedy AH Nature 2021[Jul]; 595 (7867): 421-425 PMID34030176show ga Long-lived bone marrow plasma cells (BMPCs) are a persistent and essential source of protective antibodies(1-7). Individuals who have recovered from COVID-19 have a substantially lower risk of reinfection with SARS-CoV-2(8-10). Nonetheless, it has been reported that levels of anti-SARS-CoV-2 serum antibodies decrease rapidly in the first few months after infection, raising concerns that long-lived BMPCs may not be generated and humoral immunity against SARS-CoV-2 may be short-lived(11-13). Here we show that in convalescent individuals who had experienced mild SARS-CoV-2 infections (n = 77), levels of serum anti-SARS-CoV-2 spike protein (S) antibodies declined rapidly in the first 4 months after infection and then more gradually over the following 7 months, remaining detectable at least 11 months after infection. Anti-S antibody titres correlated with the frequency of S-specific plasma cells in bone marrow aspirates from 18 individuals who had recovered from COVID-19 at 7 to 8 months after infection. S-specific BMPCs were not detected in aspirates from 11 healthy individuals with no history of SARS-CoV-2 infection. We show that S-binding BMPCs are quiescent, which suggests that they are part of a stable compartment. Consistently, circulating resting memory B cells directed against SARS-CoV-2 S were detected in the convalescent individuals. Overall, our results indicate that mild infection with SARS-CoV-2 induces robust antigen-specific, long-lived humoral immune memory in humans. |Adult[MESH] |Aged[MESH] |Bone Marrow Cells/*cytology/*immunology[MESH] |COVID-19/*immunology[MESH] |Cell Survival[MESH] |Female[MESH] |Humans[MESH] |Immunologic Memory[MESH] |Male[MESH] |Middle Aged[MESH] |Plasma Cells/*cytology/*immunology[MESH] |SARS-CoV-2/immunology[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH]SARS-CoV-2 infection induces long-lived bone marrow plasma cells in hu(epmc).pdf DeepDyve Pubget Overpricing