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10.1126/science.abf3546 http://scihub22266oqcxt.onion/10.1126/science.abf3546 34029205!8168617!34029205     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2021 ; 372 (6548): 1306-1313 Nephropedia Template TP {{tp|p=34029205|t=2021. Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome |pdf=|usr=}}{{34029205}} gab.com Text Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=34029205 #FOAvip Programmed ribosomal frameshifting is a key event during translation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA genome that allows synthesis of the viral RNA-dependent RNA polymerase and downstream proteins. Here, we present the cryo-electron microscopy structure of a translating mammalian ribosome primed for frameshifting on the viral RNA. The viral RNA adopts a pseudoknot structure that lodges at the entry to the ribosomal messenger RNA (mRNA) channel to generate tension in the mRNA and promote frameshifting, whereas the nascent viral polyprotein forms distinct interactions with the ribosomal tunnel. Biochemical experiments validate the structural observations and reveal mechanistic and regulatory features that influence frameshifting efficiency. Finally, we compare compounds previously shown to reduce frameshifting with respect to their ability to inhibit SARS-CoV-2 replication, establishing coronavirus frameshifting as a target for antiviral intervention. Twit Text FOAVip Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome ????Science http://www.kidney.de/pget.php?&tw=1&pmid=34029205 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34029205 #FOAvip English Wikipedia <ref>{{Cite pmid|34029205}}</ref> Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome #MMPMID34029205 Bhatt PR; Scaiola A; Loughran G; Leibundgut M; Kratzel A; Meurs R; Dreos R; O'Connor KM; McMillan A; Bode JW; Thiel V; Gatfield D; Atkins JF; Ban N Science 2021[Jun]; 372 (6548): 1306-1313 PMID34029205show ga Programmed ribosomal frameshifting is a key event during translation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA genome that allows synthesis of the viral RNA-dependent RNA polymerase and downstream proteins. Here, we present the cryo-electron microscopy structure of a translating mammalian ribosome primed for frameshifting on the viral RNA. The viral RNA adopts a pseudoknot structure that lodges at the entry to the ribosomal messenger RNA (mRNA) channel to generate tension in the mRNA and promote frameshifting, whereas the nascent viral polyprotein forms distinct interactions with the ribosomal tunnel. Biochemical experiments validate the structural observations and reveal mechanistic and regulatory features that influence frameshifting efficiency. Finally, we compare compounds previously shown to reduce frameshifting with respect to their ability to inhibit SARS-CoV-2 replication, establishing coronavirus frameshifting as a target for antiviral intervention. |*Frameshifting, Ribosomal/drug effects[MESH] |Animals[MESH] |Antiviral Agents/pharmacology[MESH] |Codon, Terminator[MESH] |Coronavirus RNA-Dependent RNA Polymerase/biosynthesis/chemistry/genetics[MESH] |Cryoelectron Microscopy[MESH] |Fluoroquinolones/pharmacology[MESH] |Genome, Viral[MESH] |Humans[MESH] |Image Processing, Computer-Assisted[MESH] |Models, Molecular[MESH] |Nucleic Acid Conformation[MESH] |Open Reading Frames[MESH] |Protein Folding[MESH] |RNA, Messenger/chemistry/genetics/metabolism[MESH] |RNA, Ribosomal, 18S/chemistry/genetics/metabolism[MESH] |RNA, Viral/chemistry/*genetics/metabolism[MESH] |Ribosomal Proteins/metabolism[MESH] |Ribosomes/metabolism/*ultrastructure[MESH] |SARS-CoV-2/drug effects/*genetics/physiology[MESH] |Viral Proteins/*biosynthesis/chemistry/genetics[MESH]Structural basis of ribosomal frameshifting during translation of the (epmc).pdf DeepDyve Pubget Overpricing