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10.1152/ajprenal.00077.2021 http://scihub22266oqcxt.onion/10.1152/ajprenal.00077.2021 34029142!8321805!34029142     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2021 ; 321 (1): F50-F68 Nephropedia Template TP {{tp|p=34029142|t=2021. Landscape of GPCR expression along the mouse nephron |pdf=|usr=}}{{34029142}} gab.com Text Landscape of GPCR expression along the mouse nephron JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=34029142 #FOAvip Kidney transport and other renal functions are regulated by multiple G protein-coupled receptors (GPCRs) expressed along the renal tubule. The rapid, recent appearance of comprehensive unbiased gene expression data in the various renal tubule segments, chiefly RNA sequencing and protein mass spectrometry data, has provided a means of identifying patterns of GPCR expression along the renal tubule. To allow for comprehensive mapping, we first curated a comprehensive list of GPCRs in the genomes of mice, rats, and humans (https://hpcwebapps.cit.nih.gov/ESBL/Database/GPCRs/) using multiple online data sources. We used this list to mine segment-specific and cell type-specific expression data from RNA-sequencing studies in microdissected mouse tubule segments to identify GPCRs that are selectively expressed in discrete tubule segments. Comparisons of these mapped mouse GPCRs with other omics datasets as well as functional data from isolated perfused tubule and micropuncture studies confirmed patterns of expression for well-known receptors and identified poorly studied GPCRs that are likely to play roles in the regulation of renal tubule function. Thus, we provide data resources for GPCR expression across the renal tubule, highlighting both well-known GPCRs and understudied receptors to provide guidance for future studies. Twit Text FOAVip Landscape of GPCR expression along the mouse nephron ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=34029142 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34029142 #FOAvip English Wikipedia <ref>{{Cite pmid|34029142}}</ref> Landscape of GPCR expression along the mouse nephron #MMPMID34029142 Poll BG; Chen L; Chou CL; Raghuram V; Knepper MA Am J Physiol Renal Physiol 2021[Jul]; 321 (1): F50-F68 PMID34029142show ga Kidney transport and other renal functions are regulated by multiple G protein-coupled receptors (GPCRs) expressed along the renal tubule. The rapid, recent appearance of comprehensive unbiased gene expression data in the various renal tubule segments, chiefly RNA sequencing and protein mass spectrometry data, has provided a means of identifying patterns of GPCR expression along the renal tubule. To allow for comprehensive mapping, we first curated a comprehensive list of GPCRs in the genomes of mice, rats, and humans (https://hpcwebapps.cit.nih.gov/ESBL/Database/GPCRs/) using multiple online data sources. We used this list to mine segment-specific and cell type-specific expression data from RNA-sequencing studies in microdissected mouse tubule segments to identify GPCRs that are selectively expressed in discrete tubule segments. Comparisons of these mapped mouse GPCRs with other omics datasets as well as functional data from isolated perfused tubule and micropuncture studies confirmed patterns of expression for well-known receptors and identified poorly studied GPCRs that are likely to play roles in the regulation of renal tubule function. Thus, we provide data resources for GPCR expression across the renal tubule, highlighting both well-known GPCRs and understudied receptors to provide guidance for future studies. |Animals[MESH] |Gene Expression/physiology[MESH] |Kidney Tubules, Collecting/*metabolism[MESH] |Kidney Tubules, Proximal/*metabolism[MESH] |Kidney/metabolism[MESH] |Nephrons/*metabolism[MESH]Landscape of GPCR expression along the mouse nephron (epmc).pdf DeepDyve Pubget Overpricing