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10.1172/jci.insight.147535 http://scihub22266oqcxt.onion/10.1172/jci.insight.147535 34027897!8262322!34027897     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight 2021 ; 6 (10): ä Nephropedia Template TP {{tp|p=34027897|t=2021. The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2-infected patients by sex and age |pdf=|usr=}}{{34027897}} gab.com Text The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2-infected patients by sex and age JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=34027897 #FOAvip The fact that the COVID-19 fatality rate varies by sex and age is poorly understood. Notably, the outcome of SARS-CoV-2 infections mostly depends on the control of cytokine storm and the increasingly recognized pathological role of uncontrolled neutrophil activation. Here, we used an integrative approach with publicly available RNA-Seq data sets of nasopharyngeal swabs and peripheral blood leukocytes from patients with SARS-CoV-2, according to sex and age. Female and young patients infected by SARS-CoV-2 exhibited a larger number of differentially expressed genes (DEGs) compared with male and elderly patients, indicating a stronger immune modulation. Among them, we found an association between upregulated cytokine/chemokine- and downregulated neutrophil-related DEGs. This was correlated with a closer relationship between female and young subjects, while the relationship between male and elderly patients was closer still. The association between these cytokine/chemokines and neutrophil DEGs is marked by a strongly correlated interferome network. Here, female patients exhibited reduced transcriptional levels of key proinflammatory/neutrophil-related genes, such as CXCL8 receptors (CXCR1 and CXCR2), IL-1beta, S100A9, ITGAM, and DBNL, compared with male patients. These genes are well known to be protective against inflammatory damage. Therefore, our work suggests specific immune-regulatory pathways associated with sex and age of patients infected with SARS-CoV-2 and provides a possible association between inverse modulation of cytokine/chemokine and neutrophil transcriptional signatures. Twit Text FOAVip The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2-infected patients by sex and age ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=34027897 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34027897 #FOAvip English Wikipedia <ref>{{Cite pmid|34027897}}</ref> The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2-infected patients by sex and age #MMPMID34027897 Freire PP; Marques AH; Baiocchi GC; Schimke LF; Fonseca DL; Salgado RC; Filgueiras IS; Napoleao SM; Placa DR; Akashi KT; Hirata TDC; El Khawanky N; Giil LM; Cabral-Miranda G; Carvalho RF; Ferreira LCS; Condino-Neto A; Nakaya HI; Jurisica I; Ochs HD; Camara NOS; Calich VLG; Cabral-Marques O JCI Insight 2021[May]; 6 (10): ä PMID34027897show ga The fact that the COVID-19 fatality rate varies by sex and age is poorly understood. Notably, the outcome of SARS-CoV-2 infections mostly depends on the control of cytokine storm and the increasingly recognized pathological role of uncontrolled neutrophil activation. Here, we used an integrative approach with publicly available RNA-Seq data sets of nasopharyngeal swabs and peripheral blood leukocytes from patients with SARS-CoV-2, according to sex and age. Female and young patients infected by SARS-CoV-2 exhibited a larger number of differentially expressed genes (DEGs) compared with male and elderly patients, indicating a stronger immune modulation. Among them, we found an association between upregulated cytokine/chemokine- and downregulated neutrophil-related DEGs. This was correlated with a closer relationship between female and young subjects, while the relationship between male and elderly patients was closer still. The association between these cytokine/chemokines and neutrophil DEGs is marked by a strongly correlated interferome network. Here, female patients exhibited reduced transcriptional levels of key proinflammatory/neutrophil-related genes, such as CXCL8 receptors (CXCR1 and CXCR2), IL-1beta, S100A9, ITGAM, and DBNL, compared with male patients. These genes are well known to be protective against inflammatory damage. Therefore, our work suggests specific immune-regulatory pathways associated with sex and age of patients infected with SARS-CoV-2 and provides a possible association between inverse modulation of cytokine/chemokine and neutrophil transcriptional signatures. |*Gene Regulatory Networks[MESH] |Adult[MESH] |Age Factors[MESH] |Aged[MESH] |COVID-19/epidemiology/*genetics/immunology[MESH] |Cytokines/*genetics/immunology[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Neutrophils/immunology/metabolism[MESH] |SARS-CoV-2/immunology/isolation & purification[MESH] |Sex Factors[MESH]The relationship between cytokine and neutrophil gene network distingu(epmc).pdf DeepDyve Pubget Overpricing