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10.1016/j.xcrm.2021.100311 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2021.100311 34027498!8126173!34027498     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2021 ; 2 (6): 100311 Nephropedia Template TP {{tp|p=34027498|t=2021. Highly specific monoclonal antibodies and epitope identification against SARS-CoV-2 nucleocapsid protein for antigen detection tests |pdf=|usr=}}{{34027498}} gab.com Text Highly specific monoclonal antibodies and epitope identification against SARS-CoV-2 nucleocapsid protein for antigen detection tests JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=34027498 #FOAvip The ongoing coronavirus disease 2019 (COVID-19) pandemic is a major global public health concern. Although rapid point-of-care testing for detecting viral antigen is important for management of the outbreak, the current antigen tests are less sensitive than nucleic acid testing. In our current study, we produce monoclonal antibodies (mAbs) that exclusively react with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and exhibit no cross-reactivity with other human coronaviruses, including SARS-CoV. Molecular modeling suggests that the mAbs bind to epitopes present on the exterior surface of the nucleocapsid, making them suitable for detecting SARS-CoV-2 in clinical samples. We further select the optimal pair of anti-SARS-CoV-2 nucleocapsid protein (NP) mAbs using ELISA and then use this mAb pair to develop immunochromatographic assay augmented with silver amplification technology. Our mAbs recognize the variants of concern (501Y.V1-V3) that are currently in circulation. Because of their high performance, the mAbs of this study can serve as good candidates for developing antigen detection kits for COVID-19. Twit Text FOAVip Highly specific monoclonal antibodies and epitope identification against SARS-CoV-2 nucleocapsid protein for antigen detection tests ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=34027498 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34027498 #FOAvip English Wikipedia <ref>{{Cite pmid|34027498}}</ref> Highly specific monoclonal antibodies and epitope identification against SARS-CoV-2 nucleocapsid protein for antigen detection tests #MMPMID34027498 Yamaoka Y; Miyakawa K; Jeremiah SS; Funabashi R; Okudela K; Kikuchi S; Katada J; Wada A; Takei T; Nishi M; Shimizu K; Ozawa H; Usuku S; Kawakami C; Tanaka N; Morita T; Hayashi H; Mitsui H; Suzuki K; Aizawa D; Yoshimura Y; Miyazaki T; Yamazaki E; Suzuki T; Kimura H; Shimizu H; Okabe N; Hasegawa H; Ryo A Cell Rep Med 2021[Jun]; 2 (6): 100311 PMID34027498show ga The ongoing coronavirus disease 2019 (COVID-19) pandemic is a major global public health concern. Although rapid point-of-care testing for detecting viral antigen is important for management of the outbreak, the current antigen tests are less sensitive than nucleic acid testing. In our current study, we produce monoclonal antibodies (mAbs) that exclusively react with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and exhibit no cross-reactivity with other human coronaviruses, including SARS-CoV. Molecular modeling suggests that the mAbs bind to epitopes present on the exterior surface of the nucleocapsid, making them suitable for detecting SARS-CoV-2 in clinical samples. We further select the optimal pair of anti-SARS-CoV-2 nucleocapsid protein (NP) mAbs using ELISA and then use this mAb pair to develop immunochromatographic assay augmented with silver amplification technology. Our mAbs recognize the variants of concern (501Y.V1-V3) that are currently in circulation. Because of their high performance, the mAbs of this study can serve as good candidates for developing antigen detection kits for COVID-19. |Animals[MESH] |Antibodies, Monoclonal/*immunology[MESH] |Antigen-Antibody Reactions[MESH] |COVID-19/pathology/virology[MESH] |Coronavirus Nucleocapsid Proteins/genetics/*immunology/metabolism[MESH] |Epitopes/*immunology[MESH] |Humans[MESH] |Immunization[MESH] |Immunoassay/*methods[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Phosphoproteins/genetics/immunology/metabolism[MESH] |Point-of-Care Systems[MESH] |SARS-CoV-2/isolation & purification/*metabolism[MESH]Highly specific monoclonal antibodies and epitope identification again(epmc).pdf DeepDyve Pubget Overpricing