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10.22037/aaem.v9i1.1108 http://scihub22266oqcxt.onion/10.22037/aaem.v9i1.1108 34027422!8126352!34027422     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arch+Acad+Emerg+Med 2021 ; 9 (1): e27 Nephropedia Template TP {{tp|p=34027422|t=2021. Platelet and Haemostasis are the Main Targets in Severe Cases of COVID-19 Infection; a System Biology Study |pdf=|usr=}}{{34027422}} gab.com Text Platelet and Haemostasis are the Main Targets in Severe Cases of COVID-19 Infection; a System Biology Study JO: Arch Acad Emerg Med http://www.kidney.de/pget.php?&tw=1&pmid=34027422 #FOAvip INTRODUCTION: Many proteomics-based and bioinformatics-based efforts are made to detect the molecular mechanism of COVID-19 infection. Identification of the main protein targets and pathways of severe cases of COVID-19 infection is the aim of this study. METHODS: Published differentially expressed proteins were screened and the significant proteins were investigated via protein-protein interaction network using Cytoscape software V. 3.7.2 and STRING database. The studied proteins were assessed via action map analysis to determine the relationship between individual proteins using CluePedia. The related biological terms were investigated using ClueGO and the terms were clustered and discussed. RESULTS: Among the 35 queried proteins, six of them (FGA, FGB, FGG, and FGl1 plus TLN1 and THBS1) were identified as critical proteins. A total of 38 biological terms, clustered in 4 groups, were introduced as the affected terms. "Platelet degranulation" and "hereditary factor I deficiency disease" were introduced as the main class of the terms disturbed by COVID-19 virus. CONCLUSION: It can be concluded that platelet damage and disturbed haemostasis could be the main targets in severe cases of coronavirus infection. It is vital to follow patients' condition by examining the introduced critical differentially expressed proteins (DEPs). Twit Text FOAVip Platelet and Haemostasis are the Main Targets in Severe Cases of COVID-19 Infection; a System Biology Study ????Arch Acad Emerg Med http://www.kidney.de/pget.php?&tw=1&pmid=34027422 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34027422 #FOAvip English Wikipedia <ref>{{Cite pmid|34027422}}</ref> Platelet and Haemostasis are the Main Targets in Severe Cases of COVID-19 Infection; a System Biology Study #MMPMID34027422 Zamanian-Azodi M; Arjmand B; Razzaghi M; Rezaei Tavirani M; Ahmadzadeh A; Rostaminejad M Arch Acad Emerg Med 2021[]; 9 (1): e27 PMID34027422show ga INTRODUCTION: Many proteomics-based and bioinformatics-based efforts are made to detect the molecular mechanism of COVID-19 infection. Identification of the main protein targets and pathways of severe cases of COVID-19 infection is the aim of this study. METHODS: Published differentially expressed proteins were screened and the significant proteins were investigated via protein-protein interaction network using Cytoscape software V. 3.7.2 and STRING database. The studied proteins were assessed via action map analysis to determine the relationship between individual proteins using CluePedia. The related biological terms were investigated using ClueGO and the terms were clustered and discussed. RESULTS: Among the 35 queried proteins, six of them (FGA, FGB, FGG, and FGl1 plus TLN1 and THBS1) were identified as critical proteins. A total of 38 biological terms, clustered in 4 groups, were introduced as the affected terms. "Platelet degranulation" and "hereditary factor I deficiency disease" were introduced as the main class of the terms disturbed by COVID-19 virus. CONCLUSION: It can be concluded that platelet damage and disturbed haemostasis could be the main targets in severe cases of coronavirus infection. It is vital to follow patients' condition by examining the introduced critical differentially expressed proteins (DEPs). äPlatelet and Haemostasis are the Main Targets in Severe Cases of COVID(epmc).pdf DeepDyve Pubget Overpricing