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10.3389/fmicb.2021.661187 http://scihub22266oqcxt.onion/10.3389/fmicb.2021.661187 34025615!8137897!34025615     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Microbiol 2021 ; 12 (ä): 661187 Nephropedia Template TP {{tp|p=34025615|t=2021. Sustained Neutralizing Antibodies 6 Months Following Infection in 376 Japanese COVID-19 Survivors |pdf=|usr=}}{{34025615}} gab.com Text Sustained Neutralizing Antibodies 6 Months Following Infection in 376 Japanese COVID-19 Survivors JO: Front Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=34025615 #FOAvip Objective: There is scarce evidence regarding the long-term persistence of neutralizing antibodies among coronavirus disease 2019 (COVID-19) survivors. This study determined neutralizing antibody titers (NT(50)) and antibodies against spike protein (SP) or nucleocapsid protein (NP) antigens approximately 6 months after the diagnosis of COVID-19. Methods: COVID-19 survivors in Japan were recruited. Serum samples and data related to patients' characteristics and COVID-19 history were collected. NT(50) and titers of antibodies against NP and SP antigens were measured at 20-32 weeks after the first positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test results. Factors associated with NT(50) were identified using the multivariable linear regression and the correlations among NT(50) and titers of immunoglobulin G (IgG) and total immunoglobulins (Igs) against NP and SP were assessed by Spearman's correlation. Results: Among 376 participants (median [range] days after testing positive for SARS-CoV-2, 180 (147-224); median [range] years of age, 50 (20-78); 188 [50%] male), most tested positive for NT(50) (n = 367, 98%), SP-IgG (n = 344, 91%), SP-total Ig (n = 369, 98%), NP-IgG (n = 314, 84%), and NP-total Ig (n = 365, 97%). Regression analysis indicated that higher BMI, fever, and the requirement of mechanical ventilation or extracorporeal membrane oxygenation were significantly associated with higher NT(50). Anti-SP antibodies correlated moderately with NT(50) (Spearman's correlation: 0.63 for SP IgG; 0.57 for SP-total Ig), while the correlation was weak for anti-NP antibodies (0.37 for NP IgG; 0.32 for NP-total Ig). Conclusions: Most COVID-19 survivors had sustained neutralizing antibodies and tested positive for SP-total Ig and NP-total Ig approximately 6 months after infection. Twit Text FOAVip Sustained Neutralizing Antibodies 6 Months Following Infection in 376 Japanese COVID-19 Survivors ????Front Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=34025615 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34025615 #FOAvip English Wikipedia <ref>{{Cite pmid|34025615}}</ref> Sustained Neutralizing Antibodies 6 Months Following Infection in 376 Japanese COVID-19 Survivors #MMPMID34025615 Goto A; Go H; Miyakawa K; Yamaoka Y; Ohtake N; Kubo S; Jeremiah SS; Mihara T; Senuki K; Miyazaki T; Ikeda S; Ogura T; Kato H; Matsuba I; Sanno N; Miyakawa M; Ozaki H; Kikuoka M; Ohashi Y; Ryo A; Yamanaka T Front Microbiol 2021[]; 12 (ä): 661187 PMID34025615show ga Objective: There is scarce evidence regarding the long-term persistence of neutralizing antibodies among coronavirus disease 2019 (COVID-19) survivors. This study determined neutralizing antibody titers (NT(50)) and antibodies against spike protein (SP) or nucleocapsid protein (NP) antigens approximately 6 months after the diagnosis of COVID-19. Methods: COVID-19 survivors in Japan were recruited. Serum samples and data related to patients' characteristics and COVID-19 history were collected. NT(50) and titers of antibodies against NP and SP antigens were measured at 20-32 weeks after the first positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test results. Factors associated with NT(50) were identified using the multivariable linear regression and the correlations among NT(50) and titers of immunoglobulin G (IgG) and total immunoglobulins (Igs) against NP and SP were assessed by Spearman's correlation. Results: Among 376 participants (median [range] days after testing positive for SARS-CoV-2, 180 (147-224); median [range] years of age, 50 (20-78); 188 [50%] male), most tested positive for NT(50) (n = 367, 98%), SP-IgG (n = 344, 91%), SP-total Ig (n = 369, 98%), NP-IgG (n = 314, 84%), and NP-total Ig (n = 365, 97%). Regression analysis indicated that higher BMI, fever, and the requirement of mechanical ventilation or extracorporeal membrane oxygenation were significantly associated with higher NT(50). Anti-SP antibodies correlated moderately with NT(50) (Spearman's correlation: 0.63 for SP IgG; 0.57 for SP-total Ig), while the correlation was weak for anti-NP antibodies (0.37 for NP IgG; 0.32 for NP-total Ig). Conclusions: Most COVID-19 survivors had sustained neutralizing antibodies and tested positive for SP-total Ig and NP-total Ig approximately 6 months after infection. äSustained Neutralizing Antibodies 6 Months Following Infection in 376 (epmc).pdf DeepDyve Pubget Overpricing