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10.1016/j.clnesp.2021.02.021 http://scihub22266oqcxt.onion/10.1016/j.clnesp.2021.02.021 34024514!7959677!34024514     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Nutr+ESPEN 2021 ; 43 (ä): 197-199 Nephropedia Template TP {{tp|p=34024514|t=2021. Glucose-6-phosphate dehydrogenase inhibitor for treatment of severe COVID-19: Polydatin |pdf=|usr=}}{{34024514}} gab.com Text Glucose-6-phosphate dehydrogenase inhibitor for treatment of severe COVID-19: Polydatin JO: Clin Nutr ESPEN http://www.kidney.de/pget.php?&tw=1&pmid=34024514 #FOAvip The COVID-19 pandemic as the largest global public health crisis is now considered as an emergency at the World Health Organization (WHO). As there is no specific therapy for SARS-CoV-2 infection at present and also because of the long time it takes to discover a new drug and the urgent need to respond urgently to a pandemic infection. Perhaps the best way right now is to find an FDA-approved drug to treat this infection. Oxidative stress and inflammation play a vital role in the progression of tissue injury in COVID-19 patients; furthermore, the G6PD activation is related to increased oxidative inflammation in acute pulmonary injury. In this regard, we propose a new insight that may be a good strategy for this urgency. Exploiting G6PD through inhibiting G6PD activity by modifying redox balance, metabolic switching and protein-protein interactions can be proposed as a new approach to improving patients in severe stage of COVID 19 through various mechanisms. Polydatin is isolated from many plants such as Polygonum, peanuts, grapes, red wines and many daily diets that can be used in severe stage of COVID-19 as a G6PD inhibitor. Furthermore, polydatin possesses various biological activities such as anti-inflammatory, antioxidant, immunoregulatory, nephroprotective, hepatoprotective, anti-arrhythmic and anti-tumor. Our hypothesis is that the consumption of antioxidants such as Polydatin (a glucoside of resveratrol) as a complementary therapeutic approach may be effective in reducing oxidative stress and inflammation in patients with COVID-19. Twit Text FOAVip Glucose-6-phosphate dehydrogenase inhibitor for treatment of severe COVID-19: Polydatin ????Clin Nutr ESPEN http://www.kidney.de/pget.php?&tw=1&pmid=34024514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34024514 #FOAvip English Wikipedia <ref>{{Cite pmid|34024514}}</ref> Glucose-6-phosphate dehydrogenase inhibitor for treatment of severe COVID-19: Polydatin #MMPMID34024514 Doustimotlagh AH; Eftekhari M Clin Nutr ESPEN 2021[Jun]; 43 (ä): 197-199 PMID34024514show ga The COVID-19 pandemic as the largest global public health crisis is now considered as an emergency at the World Health Organization (WHO). As there is no specific therapy for SARS-CoV-2 infection at present and also because of the long time it takes to discover a new drug and the urgent need to respond urgently to a pandemic infection. Perhaps the best way right now is to find an FDA-approved drug to treat this infection. Oxidative stress and inflammation play a vital role in the progression of tissue injury in COVID-19 patients; furthermore, the G6PD activation is related to increased oxidative inflammation in acute pulmonary injury. In this regard, we propose a new insight that may be a good strategy for this urgency. Exploiting G6PD through inhibiting G6PD activity by modifying redox balance, metabolic switching and protein-protein interactions can be proposed as a new approach to improving patients in severe stage of COVID 19 through various mechanisms. Polydatin is isolated from many plants such as Polygonum, peanuts, grapes, red wines and many daily diets that can be used in severe stage of COVID-19 as a G6PD inhibitor. Furthermore, polydatin possesses various biological activities such as anti-inflammatory, antioxidant, immunoregulatory, nephroprotective, hepatoprotective, anti-arrhythmic and anti-tumor. Our hypothesis is that the consumption of antioxidants such as Polydatin (a glucoside of resveratrol) as a complementary therapeutic approach may be effective in reducing oxidative stress and inflammation in patients with COVID-19. |*COVID-19 Drug Treatment[MESH] |*Phytotherapy[MESH] |Anti-Inflammatory Agents/pharmacology/therapeutic use[MESH] |Antioxidants/pharmacology/*therapeutic use[MESH] |COVID-19/complications/metabolism[MESH] |Glucosephosphate Dehydrogenase/*antagonists & inhibitors[MESH] |Glucosides/pharmacology/*therapeutic use[MESH] |Humans[MESH] |Inflammation/drug therapy/etiology/metabolism[MESH] |Lung/drug effects[MESH] |Magnoliopsida/chemistry[MESH] |Oxidative Stress/drug effects[MESH] |Pandemics[MESH] |Plant Extracts/pharmacology/*therapeutic use[MESH] |Resveratrol/pharmacology/*therapeutic use[MESH] |SARS-CoV-2[MESH]Glucose-6-phosphate dehydrogenase inhibitor for treatment of severe CO(epmc).pdf DeepDyve Pubget Overpricing