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10.1007/s00109-021-02092-0 http://scihub22266oqcxt.onion/10.1007/s00109-021-02092-0 34023935!8140746!34023935     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34023935&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34023935.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Mol+Med+(Berl) 2021 ; 99 (8): 1023-1031 Nephropedia Template TP {{tp|p=34023935|t=2021. Glycosylation is a key in SARS-CoV-2 infection |pdf=|usr=}}{{34023935}} gab.com Text Glycosylation is a key in SARS-CoV-2 infection JO: J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=34023935 #FOAvip SARS-CoV-2 causes the respiratory syndrome COVID-19 and is responsible for the current pandemic. The S protein of SARS-CoV-2-mediating virus binding to target cells and subsequent viral uptake is extensively glycosylated. Here we focus on how glycosylation of both SARS-CoV-2 and target cells crucially impacts SARS-CoV-2 infection at different levels: (1) virus binding and entry to host cells, with glycosaminoglycans of host cells acting as a necessary co-factor for SARS-CoV-2 infection by interacting with the receptor-binding domain of the SARS-CoV-2 spike glycoprotein, (2) innate and adaptive immune response where glycosylation plays both a protective role and contributes to immune evasion by masking of viral polypeptide epitopes and may add to the cytokine cascade via non-fucosylated IgG, and (3) therapy and vaccination where a monoclonal antibody-neutralizing SARS-CoV-2 was shown to interact also with a distinct glycan epitope on the SARS-CoV-2 spike protein. These evidences highlight the importance of ensuring that glycans are considered when tackling this disease, particularly in the development of vaccines, therapeutic strategies and serological testing. Twit Text FOAVip Glycosylation is a key in SARS-CoV-2 infection ????J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=34023935 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34023935 #FOAvip English Wikipedia <ref>{{Cite pmid|34023935}}</ref> Glycosylation is a key in SARS-CoV-2 infection #MMPMID34023935 Reis CA; Tauber R; Blanchard V J Mol Med (Berl) 2021[Aug]; 99 (8): 1023-1031 PMID34023935show ga SARS-CoV-2 causes the respiratory syndrome COVID-19 and is responsible for the current pandemic. The S protein of SARS-CoV-2-mediating virus binding to target cells and subsequent viral uptake is extensively glycosylated. Here we focus on how glycosylation of both SARS-CoV-2 and target cells crucially impacts SARS-CoV-2 infection at different levels: (1) virus binding and entry to host cells, with glycosaminoglycans of host cells acting as a necessary co-factor for SARS-CoV-2 infection by interacting with the receptor-binding domain of the SARS-CoV-2 spike glycoprotein, (2) innate and adaptive immune response where glycosylation plays both a protective role and contributes to immune evasion by masking of viral polypeptide epitopes and may add to the cytokine cascade via non-fucosylated IgG, and (3) therapy and vaccination where a monoclonal antibody-neutralizing SARS-CoV-2 was shown to interact also with a distinct glycan epitope on the SARS-CoV-2 spike protein. These evidences highlight the importance of ensuring that glycans are considered when tackling this disease, particularly in the development of vaccines, therapeutic strategies and serological testing. |*Host-Pathogen Interactions[MESH] |Adaptive Immunity[MESH] |Animals[MESH] |Blood Group Antigens/immunology/metabolism[MESH] |COVID-19/immunology/*metabolism/therapy[MESH] |Exocytosis[MESH] |Glycosylation[MESH] |Humans[MESH] |Immunity, Innate[MESH] |SARS-CoV-2/immunology/*physiology[MESH] |Spike Glycoprotein, Coronavirus/immunology/metabolism[MESH] |Virus Internalization[MESH]Glycosylation is a key in SARS-CoV-2 infection (epmc).pdf DeepDyve Pubget Overpricing