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10.1016/j.jcrc.2021.04.010 http://scihub22266oqcxt.onion/10.1016/j.jcrc.2021.04.010 34023553!8061635!34023553     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Crit+Care 2021 ; 64 (ä): 219-225 Nephropedia Template TP {{tp|p=34023553|t=2021. Viral load dynamics in intubated patients with COVID-19 admitted to the intensive care unit |pdf=|usr=}}{{34023553}} gab.com Text Viral load dynamics in intubated patients with COVID-19 admitted to the intensive care unit JO: J Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=34023553 #FOAvip BACKGROUND: Prolonged viral RNA detection in respiratory samples from patients with COVID-19 has been described, but the clinical relevance remains unclear. We studied the dynamics of SARS-CoV-2 on a group and individual level in intubated ICU patients. METHODS: In a cohort of 86 patients, we analysed SARS-CoV-2 RT-PCR results on nasopharyngeal and sputum samples (obtained as part of clinical care twice a week) according to time after intubation. Subsequently, we performed survival analyses. RESULTS: 870 samples were tested by RT-PCR. Overall viral load was highest in the first week (median nasopharynx 3.5, IQR 1.5-4.3; median sputum 4.3, IQR 3.3-5.6) and decreased over time. In 20% of patients a relapsing pattern was observed. Nasopharyngeal and sputum PCR status on day 14 was not significantly associated with survival up to day 60 in this small cohort. CONCLUSION: In general SARS-CoV-2 RNA levels in respiratory samples in patients with severe COVID-19 decrease after the first week after intubation, but individual SARS-CoV-2 RNA levels can show a relapsing pattern. Larger studies are needed to address the association of clearance of SARS-CoV-2 RNA from respiratory samples with survival, because we observed a trend towards better survival in patients with early clearance from sputum. Twit Text FOAVip Viral load dynamics in intubated patients with COVID-19 admitted to the intensive care unit ????J Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=34023553 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34023553 #FOAvip English Wikipedia <ref>{{Cite pmid|34023553}}</ref> Viral load dynamics in intubated patients with COVID-19 admitted to the intensive care unit #MMPMID34023553 Boef AGC; van Wezel EM; Gard L; Netkova K; Lokate M; van der Voort PHJ; Niesters HGM; Van Leer Buter C J Crit Care 2021[Aug]; 64 (ä): 219-225 PMID34023553show ga BACKGROUND: Prolonged viral RNA detection in respiratory samples from patients with COVID-19 has been described, but the clinical relevance remains unclear. We studied the dynamics of SARS-CoV-2 on a group and individual level in intubated ICU patients. METHODS: In a cohort of 86 patients, we analysed SARS-CoV-2 RT-PCR results on nasopharyngeal and sputum samples (obtained as part of clinical care twice a week) according to time after intubation. Subsequently, we performed survival analyses. RESULTS: 870 samples were tested by RT-PCR. Overall viral load was highest in the first week (median nasopharynx 3.5, IQR 1.5-4.3; median sputum 4.3, IQR 3.3-5.6) and decreased over time. In 20% of patients a relapsing pattern was observed. Nasopharyngeal and sputum PCR status on day 14 was not significantly associated with survival up to day 60 in this small cohort. CONCLUSION: In general SARS-CoV-2 RNA levels in respiratory samples in patients with severe COVID-19 decrease after the first week after intubation, but individual SARS-CoV-2 RNA levels can show a relapsing pattern. Larger studies are needed to address the association of clearance of SARS-CoV-2 RNA from respiratory samples with survival, because we observed a trend towards better survival in patients with early clearance from sputum. |*COVID-19 Nucleic Acid Testing[MESH] |*RNA, Viral[MESH] |*SARS-CoV-2[MESH] |*Viral Load[MESH] |Aged[MESH] |COVID-19/*diagnosis/*virology[MESH] |Female[MESH] |Humans[MESH] |Intensive Care Units[MESH] |Intubation[MESH] |Male[MESH] |Middle Aged[MESH] |Nasopharynx/virology[MESH] |Netherlands/epidemiology[MESH] |Sputum/virology[MESH]Viral load dynamics in intubated patients with COVID-19 admitted to th(epmc).pdf DeepDyve Pubget Overpricing