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10.1016/j.meegid.2021.104933

http://scihub22266oqcxt.onion/10.1016/j.meegid.2021.104933
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34023511!8136293!34023511
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suck abstract from ncbi


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pmid34023511      Infect+Genet+Evol 2021 ; 93 (ä): 104933
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  • Exploration of hosts and transmission traits for SARS-CoV-2 based on the k-mer natural vector #MMPMID34023511
  • Zhang Y; Wen J; Li X; Li G
  • Infect Genet Evol 2021[Sep]; 93 (ä): 104933 PMID34023511show ga
  • A severe respiratory pneumonia COVID-19 has raged all over the world, and a coronavirus named SARS-CoV-2 is blamed for this global pandemic. Despite intensive research into the origins of the COVID-19 pandemic, the evolutionary history of its agent SARS-CoV-2 remains unclear, which is vital to control the pandemic and prevent another round of outbreak. Coronaviruses are highly recombinogenic, which are not well handled with alignment-based method. In addition, deletions have been found in the genomes of several SARS-CoV-2, which cannot be resolved with current phylogenetic methods. Therefore, the k-mer natural vector is proposed to explore hosts and transmission traits for SARS-CoV-2 using strict phylogenetic reconstruction. SARS-CoV-2 clustering with bat-origin coronaviruses strongly suggests bats to be the natural reservoir of SARS-CoV-2. By building bat-to-human transmission route, pangolin is identified as an intermediate host, and civet is predicted as a possible candidate. We speculate that SARS-CoV-2 undergoes cross-species recombination between bat and pangolin coronaviruses. This study also demonstrates transmission mode and features of SARS-CoV-2 in the COVID-19 pandemic when it broke out early around the world.
  • |*Host-Pathogen Interactions[MESH]
  • |*Phylogeny[MESH]
  • |Animals[MESH]
  • |Biological Evolution[MESH]
  • |COVID-19/epidemiology/*transmission[MESH]
  • |China[MESH]
  • |Chiroptera/virology[MESH]
  • |Coronavirus/genetics[MESH]
  • |Genome, Viral[MESH]
  • |Pangolins/virology[MESH]
  • |SARS-CoV-2/*genetics/*pathogenicity[MESH]
  • |Spike Glycoprotein, Coronavirus/genetics[MESH]
  • |Viral Zoonoses/transmission[MESH]


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