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10.1016/j.jmb.2021.167058 http://scihub22266oqcxt.onion/10.1016/j.jmb.2021.167058 34023401!8139174!34023401     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Biol 2021 ; 433 (15): 167058 Nephropedia Template TP {{tp|p=34023401|t=2021. Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreading SARS-CoV-2 Variants |pdf=|usr=}}{{34023401}} gab.com Text Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreading SARS-CoV-2 Variants JO: J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=34023401 #FOAvip Rapidly spreading new variants of SARS-CoV-2 carry multiple mutations in the viral spike protein which attaches to the angiotensin converting enzyme 2 (ACE2) receptor on host cells. Among these mutations are amino acid changes N501Y (lineage B.1.1.7, first identified in the UK), and the combination N501Y, E484K, K417N (B.1.351, first identified in South Africa), all located at the interface on the receptor binding domain (RBD). We experimentally establish that RBD containing the N501Y mutation results in 7-fold stronger binding to the hACE2 receptor than wild type RBD. The E484K mutation only slightly enhances the affinity for the receptor, while K417N attenuates affinity. As a result, RBD from B.1.351 containing all three mutations binds 3-fold stronger to hACE2 than wild type RBD but 2-fold weaker than N501Y. However, the recently emerging double mutant E484K/N501Y binds even stronger than N501Y. The independent evolution of lineages containing mutations with different effects on receptor binding affinity, viral transmission and immune evasion underscores the importance of global viral genome surveillance and functional characterization. Twit Text FOAVip Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreading SARS-CoV-2 Variants ????J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=34023401 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34023401 #FOAvip English Wikipedia <ref>{{Cite pmid|34023401}}</ref> Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreading SARS-CoV-2 Variants #MMPMID34023401 Laffeber C; de Koning K; Kanaar R; Lebbink JHG J Mol Biol 2021[Jul]; 433 (15): 167058 PMID34023401show ga Rapidly spreading new variants of SARS-CoV-2 carry multiple mutations in the viral spike protein which attaches to the angiotensin converting enzyme 2 (ACE2) receptor on host cells. Among these mutations are amino acid changes N501Y (lineage B.1.1.7, first identified in the UK), and the combination N501Y, E484K, K417N (B.1.351, first identified in South Africa), all located at the interface on the receptor binding domain (RBD). We experimentally establish that RBD containing the N501Y mutation results in 7-fold stronger binding to the hACE2 receptor than wild type RBD. The E484K mutation only slightly enhances the affinity for the receptor, while K417N attenuates affinity. As a result, RBD from B.1.351 containing all three mutations binds 3-fold stronger to hACE2 than wild type RBD but 2-fold weaker than N501Y. However, the recently emerging double mutant E484K/N501Y binds even stronger than N501Y. The independent evolution of lineages containing mutations with different effects on receptor binding affinity, viral transmission and immune evasion underscores the importance of global viral genome surveillance and functional characterization. |*Amino Acid Substitution[MESH] |Angiotensin-Converting Enzyme 2/chemistry/genetics/*metabolism[MESH] |Binding Sites[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Hydrogen Bonding[MESH] |Models, Molecular[MESH] |Protein Binding[MESH] |Protein Conformation[MESH] |Protein Domains[MESH] |SARS-CoV-2/classification/genetics/*metabolism[MESH]Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreadi(epmc).pdf DeepDyve Pubget Overpricing