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10.1016/j.ijid.2021.05.034 http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.05.034 34022331!8132551!34022331     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34022331&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Int+J+Infect+Dis 2021 ; 108 (?): 183-186 Nephropedia Template TP {{tp|p=34022331|t=2021. Immunological memory and neutralizing activity to a single dose of COVID-19 vaccine in previously infected individuals |pdf=|usr=}}{{34022331}} gab.com Text Immunological memory and neutralizing activity to a single dose of COVID-19 vaccine in previously infected individuals JO: Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34022331 #FOAvip BACKGROUND: The efficacy of COVID-19 vaccines to generate immunological memory post-vaccination has not previously been studied. OBJECTIVE: To assess immunological memory in previously SARS-CoV-2 infected individuals after a single dose of mRNA vaccine. PATIENTS AND METHODS: Healthcare workers (n = 280) were enrolled after obtaining written informed consent and grouped under previously infected and no prior exposure (reverse transcription-polymerase chain reaction positive and negative, respectively). Blood was drawn at baseline and post-vaccination (single dose of COVISHIELD) for enumerating neutralizing antibodies by chemiluminescence and memory T- and B-cells by flow cytometry. RESULTS: Post vaccination, compared with the no prior exposure group, the previously infected group had higher levels of: antibody response (1124.73 +/- 869.13 vs 94.23 +/- 140.06 AU/ml, p = 0.0001); CD4 memory T-cells: central memory CCR7+CD45RA- (p = 0.0001), effector memory CCR7-/CD45RA- (p = 0.01); total CD8+ T-cells (p = 0.004); CD8+ naive T-cells CCR7+CD45RA+ (p = 0.01); and memory B-cells CD20+CD27+ (p = 0.0001). DISCUSSION: Single-dose vaccination elicited higher neutralizing antibody response and protective immunity in individuals who had recovered from SARS-CoV-2 infection compared with those with no prior exposure. Twit Text FOAVip Immunological memory and neutralizing activity to a single dose of COVID-19 vaccine in previously infected individuals ????Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34022331 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34022331 #FOAvip English Wikipedia <ref>{{Cite pmid|34022331}}</ref> Immunological memory and neutralizing activity to a single dose of COVID-19 vaccine in previously infected individuals #MMPMID34022331 Sasikala M; Shashidhar J; Deepika G; Ravikanth V; Krishna VV; Sadhana Y; Pragathi K; Reddy DN Int J Infect Dis 2021[Jul]; 108 (?): 183-186 PMID34022331show ga BACKGROUND: The efficacy of COVID-19 vaccines to generate immunological memory post-vaccination has not previously been studied. OBJECTIVE: To assess immunological memory in previously SARS-CoV-2 infected individuals after a single dose of mRNA vaccine. PATIENTS AND METHODS: Healthcare workers (n = 280) were enrolled after obtaining written informed consent and grouped under previously infected and no prior exposure (reverse transcription-polymerase chain reaction positive and negative, respectively). Blood was drawn at baseline and post-vaccination (single dose of COVISHIELD) for enumerating neutralizing antibodies by chemiluminescence and memory T- and B-cells by flow cytometry. RESULTS: Post vaccination, compared with the no prior exposure group, the previously infected group had higher levels of: antibody response (1124.73 +/- 869.13 vs 94.23 +/- 140.06 AU/ml, p = 0.0001); CD4 memory T-cells: central memory CCR7+CD45RA- (p = 0.0001), effector memory CCR7-/CD45RA- (p = 0.01); total CD8+ T-cells (p = 0.004); CD8+ naive T-cells CCR7+CD45RA+ (p = 0.01); and memory B-cells CD20+CD27+ (p = 0.0001). DISCUSSION: Single-dose vaccination elicited higher neutralizing antibody response and protective immunity in individuals who had recovered from SARS-CoV-2 infection compared with those with no prior exposure. |*COVID-19[MESH] |*COVID-19 Vaccines[MESH] |Antibodies, Viral[MESH] |CD8-Positive T-Lymphocytes[MESH] |Humans[MESH] |Immunologic Memory[MESH]Immunological memory and neutralizing activity to a single dose of COV(epmc).pdf DeepDyve Pubget Overpricing