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10.1016/j.ijid.2021.05.033

http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.05.033
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34022329!8132552!34022329
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suck abstract from ncbi


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pmid34022329      Int+J+Infect+Dis 2021 ; 108 (ä): 176-178
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  • Single-dose BNT162b2 mRNA COVID-19 vaccine significantly boosts neutralizing antibody response in health care workers recovering from asymptomatic or mild natural SARS-CoV-2 infection #MMPMID34022329
  • Vicenti I; Gatti F; Scaggiante R; Boccuto A; Zago D; Basso M; Dragoni F; Zazzi M; Parisi SG
  • Int J Infect Dis 2021[Jul]; 108 (ä): 176-178 PMID34022329show ga
  • OBJECTIVES: To measure SARS-CoV-2 neutralizing antibody (NtAb) titres in previously infected or uninfected health care workers who received one or two doses of BNT162b2 mRNA COVID-19 vaccine. METHODS: NtAbs were titrated as dose-inhibiting 50% virus replication (ID(50)) by live virus microneutralization. We evaluated 41 health care workers recovering from mild or asymptomatic infection at first vaccination dose (T1_inf) and 21 days later (T2_inf). Sixteen uninfected health care workers were evaluated 20 days after first dose (T2_uninf) and 20 days after second vaccine dose (T3_uninf). RESULTS: At T2_inf, but not at T1_inf, there was a significant correlation between days from diagnosis (median 313, interquartile range 285-322) and NtAb levels (P = 0.011). NtAb titres increased at T2_inf with respect to T1_inf (1544 (732-2232) vs 26 (10-88), P < 0.001). Similarly, there was a significant increase in NtAb titres at T3_uninf compared with T2_uninf (183 (111-301) vs 5 (5-15), P < 0001). However, NtAb levels at T2_inf were significantly higher than those at T2_uninf and T3_uninf (P < 0.0001 for both analyses). CONCLUSIONS: A single vaccination in people with mild or asymptomatic previous infection further boosts SARS-CoV-2 humoral immunity to levels higher than those obtained by complete two-vaccination in uninfected subjects.
  • |*COVID-19[MESH]
  • |*SARS-CoV-2[MESH]
  • |Antibodies, Neutralizing[MESH]
  • |BNT162 Vaccine[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Health Personnel[MESH]
  • |Humans[MESH]


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