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10.1016/j.chom.2021.05.004 http://scihub22266oqcxt.onion/10.1016/j.chom.2021.05.004 34022154!8126603!34022154     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34022154&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2021 ; 29 (7): 1052-1062 Nephropedia Template TP {{tp|p=34022154|t=2021. Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19 |pdf=|usr=}}{{34022154}} gab.com Text Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19 JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=34022154 #FOAvip COVID-19 can result in severe disease characterized by significant immunopathology that is spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive response. A limited and delayed interferon I (IFN-I) and IFN-III response results in exacerbated proinflammatory cytokine production and in extensive cellular infiltrates in the respiratory tract, resulting in lung pathology. The development of effective therapeutics for patients with severe COVID-19 depends on our understanding of the pathological elements of this unbalanced innate immune response. Here, we review the mechanisms by which SARS-CoV-2 both activates and antagonizes the IFN and inflammatory response following infection, how a dysregulated cytokine and cellular response contributes to immune-mediated pathology in COVID-19, and therapeutic strategies that target elements of the innate response. Twit Text FOAVip Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19 ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=34022154 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34022154 #FOAvip English Wikipedia <ref>{{Cite pmid|34022154}}</ref> Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19 #MMPMID34022154 Lowery SA; Sariol A; Perlman S Cell Host Microbe 2021[Jul]; 29 (7): 1052-1062 PMID34022154show ga COVID-19 can result in severe disease characterized by significant immunopathology that is spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive response. A limited and delayed interferon I (IFN-I) and IFN-III response results in exacerbated proinflammatory cytokine production and in extensive cellular infiltrates in the respiratory tract, resulting in lung pathology. The development of effective therapeutics for patients with severe COVID-19 depends on our understanding of the pathological elements of this unbalanced innate immune response. Here, we review the mechanisms by which SARS-CoV-2 both activates and antagonizes the IFN and inflammatory response following infection, how a dysregulated cytokine and cellular response contributes to immune-mediated pathology in COVID-19, and therapeutic strategies that target elements of the innate response. |Animals[MESH] |Anti-Inflammatory Agents/therapeutic use[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*immunology[MESH] |Cytokines/metabolism[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Immune Evasion[MESH] |Immunity, Innate/*immunology[MESH] |Interferon Lambda[MESH] |Interferon Type I/metabolism[MESH] |Interferons/metabolism/*therapeutic use[MESH] |Kinetics[MESH]Innate immune and inflammatory responses to SARS-CoV-2: Implications f(epmc).pdf DeepDyve Pubget Overpricing