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10.1007/s10096-021-04274-7

http://scihub22266oqcxt.onion/10.1007/s10096-021-04274-7
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34021840!8140309!34021840
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suck abstract from ncbi


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pmid34021840      Eur+J+Clin+Microbiol+Infect+Dis 2021 ; 40 (9): 1975-1981
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  • Clinical evaluation of rapid point-of-care antigen tests for diagnosis of SARS-CoV-2 infection #MMPMID34021840
  • Koeleman JGM; Brand H; de Man SJ; Ong DSY
  • Eur J Clin Microbiol Infect Dis 2021[Sep]; 40 (9): 1975-1981 PMID34021840show ga
  • The RT-qPCR in respiratory specimens is the gold standard for diagnosing acute COVID-19 infections. However, this test takes considerable time before test results become available, thereby delaying patients from being diagnosed, treated, and isolated immediately. Rapid antigen tests could overcome this problem. In the first study, clinical performances of five rapid antigen tests were compared to RT-qPCR in upper respiratory specimens from 40 patients with positive and 40 with negative RTq-PCR results. In the second study, the rapid antigen test with one of the best test characteristics (Romed) was evaluated in a large prospective collection of upper respiratory specimens from 900 different COVID-19-suspected patients (300 emergency room patients, 300 nursing home patients, and 300 health care workers). Test specificities ranged from 87.5 to 100.0%, and test sensitivities from 55.0 to 80.0%. The clinical specificity of the Romed test was 99.8% (95% CI 98.9-100). Overall clinical sensitivity in the study population was 73.3% (95% CI 67.9-78.2), whereas sensitivity in the different patient groups varied from 65.3 to 86.7%. Sensitivity was 83.0 to 86.7% in patients with short duration of symptoms. In a population with a COVID-19 prevalence of 1%, the negative predictive value in all patients was 99.7%. There is a large variability in diagnostic performance between rapid antigen tests. The Romed rapid antigen test showed a good clinical performance in patients with high viral loads (RT-qPCR cycle threshold
  • |*Point-of-Care Testing[MESH]
  • |Antigens, Viral/analysis[MESH]
  • |COVID-19 Serological Testing/*methods[MESH]
  • |COVID-19/*diagnosis/virology[MESH]
  • |Humans[MESH]
  • |Prospective Studies[MESH]
  • |SARS-CoV-2/genetics/*immunology/isolation & purification[MESH]


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