Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41467-021-23333-3 http://scihub22266oqcxt.onion/10.1038/s41467-021-23333-3 34021148!8140108!34021148     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 3010 Nephropedia Template TP {{tp|p=34021148|t=2021. Peripheral and lung resident memory T cell responses against SARS-CoV-2 |pdf=|usr=}}{{34021148}} gab.com Text Peripheral and lung resident memory T cell responses against SARS-CoV-2 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34021148 #FOAvip Resident memory T cells (T(RM)) positioned within the respiratory tract are probably required to limit SARS-CoV-2 spread and COVID-19. Importantly, T(RM) are mostly non-recirculating, which reduces the window of opportunity to examine these cells in the blood as they move to the lung parenchyma. Here, we identify circulating virus-specific T cell responses during acute infection with functional, migratory and apoptotic patterns modulated by viral proteins and associated with clinical outcome. Disease severity is associated predominantly with IFNgamma and IL-4 responses, increased responses against S peptides and apoptosis, whereas non-hospitalized patients have increased IL-12p70 levels, degranulation in response to N peptides and SARS-CoV-2-specific CCR7(+) T cells secreting IL-10. In convalescent patients, lung-T(RM) are frequently detected even 10 months after initial infection, in which contemporaneous blood does not reflect tissue-resident profiles. Our study highlights a balanced anti-inflammatory antiviral response associated with a better outcome and persisting T(RM) cells as important for future protection against SARS-CoV-2 infection. Twit Text FOAVip Peripheral and lung resident memory T cell responses against SARS-CoV-2 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34021148 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34021148 #FOAvip English Wikipedia <ref>{{Cite pmid|34021148}}</ref> Peripheral and lung resident memory T cell responses against SARS-CoV-2 #MMPMID34021148 Grau-Exposito J; Sanchez-Gaona N; Massana N; Suppi M; Astorga-Gamaza A; Perea D; Rosado J; Falco A; Kirkegaard C; Torrella A; Planas B; Navarro J; Suanzes P; Alvarez-Sierra D; Ayora A; Sansano I; Esperalba J; Andres C; Anton A; Ramon Y Cajal S; Almirante B; Pujol-Borrell R; Falco V; Burgos J; Buzon MJ; Genesca M Nat Commun 2021[May]; 12 (1): 3010 PMID34021148show ga Resident memory T cells (T(RM)) positioned within the respiratory tract are probably required to limit SARS-CoV-2 spread and COVID-19. Importantly, T(RM) are mostly non-recirculating, which reduces the window of opportunity to examine these cells in the blood as they move to the lung parenchyma. Here, we identify circulating virus-specific T cell responses during acute infection with functional, migratory and apoptotic patterns modulated by viral proteins and associated with clinical outcome. Disease severity is associated predominantly with IFNgamma and IL-4 responses, increased responses against S peptides and apoptosis, whereas non-hospitalized patients have increased IL-12p70 levels, degranulation in response to N peptides and SARS-CoV-2-specific CCR7(+) T cells secreting IL-10. In convalescent patients, lung-T(RM) are frequently detected even 10 months after initial infection, in which contemporaneous blood does not reflect tissue-resident profiles. Our study highlights a balanced anti-inflammatory antiviral response associated with a better outcome and persisting T(RM) cells as important for future protection against SARS-CoV-2 infection. |Apoptosis/immunology[MESH] |CD4-Positive T-Lymphocytes/immunology/metabolism[MESH] |CD8-Positive T-Lymphocytes/immunology/metabolism[MESH] |COVID-19/*immunology/virology[MESH] |Cell Movement/immunology[MESH] |Humans[MESH] |Immunologic Memory/*immunology[MESH] |Interferon-gamma/immunology/metabolism[MESH] |Interleukin-4/immunology/metabolism[MESH] |Lung/*immunology/virology[MESH] |SARS-CoV-2/*immunology/physiology[MESH]Peripheral and lung resident memory T cell responses against SARS-CoV-(epmc).pdf DeepDyve Pubget Overpricing