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10.1038/s41467-021-23334-2 http://scihub22266oqcxt.onion/10.1038/s41467-021-23334-2 34021143!8140132!34021143     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 3006 Nephropedia Template TP {{tp|p=34021143|t=2021. Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes |pdf=|usr=}}{{34021143}} gab.com Text Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34021143 #FOAvip Coronavirus disease 2019 (COVID-19) can lead to pneumonia and hyperinflammation. Here we show a sensitive method to measure polyclonal T cell activation by downstream effects on responder cells like basophils, plasmacytoid dendritic cells, monocytes and neutrophils in whole blood. We report a clear T cell hyporeactivity in hospitalized COVID-19 patients that is pronounced in ventilated patients, associated with prolonged virus persistence and reversible with clinical recovery. COVID-19-induced T cell hyporeactivity is T cell extrinsic and caused by plasma components, independent of occasional immunosuppressive medication of the patients. Monocytes respond stronger in males than females and IL-2 partially restores T cell activation. Downstream markers of T cell hyporeactivity are also visible in fresh blood samples of ventilated patients. Based on our data we developed a score to predict fatal outcomes and identify patients that may benefit from strategies to overcome T cell hyporeactivity. Twit Text FOAVip Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34021143 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34021143 #FOAvip English Wikipedia <ref>{{Cite pmid|34021143}}</ref> Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes #MMPMID34021143 Renner K; Schwittay T; Chaabane S; Gottschling J; Muller C; Tiefenbock C; Salewski JN; Winter F; Buchtler S; Balam S; Malfertheiner MV; Lubnow M; Lunz D; Graf B; Hitzenbichler F; Hanses F; Poeck H; Kreutz M; Orso E; Burkhardt R; Niedermair T; Brochhausen C; Gessner A; Salzberger B; Mack M Nat Commun 2021[May]; 12 (1): 3006 PMID34021143show ga Coronavirus disease 2019 (COVID-19) can lead to pneumonia and hyperinflammation. Here we show a sensitive method to measure polyclonal T cell activation by downstream effects on responder cells like basophils, plasmacytoid dendritic cells, monocytes and neutrophils in whole blood. We report a clear T cell hyporeactivity in hospitalized COVID-19 patients that is pronounced in ventilated patients, associated with prolonged virus persistence and reversible with clinical recovery. COVID-19-induced T cell hyporeactivity is T cell extrinsic and caused by plasma components, independent of occasional immunosuppressive medication of the patients. Monocytes respond stronger in males than females and IL-2 partially restores T cell activation. Downstream markers of T cell hyporeactivity are also visible in fresh blood samples of ventilated patients. Based on our data we developed a score to predict fatal outcomes and identify patients that may benefit from strategies to overcome T cell hyporeactivity. |Adult[MESH] |Aged[MESH] |Basophils/immunology[MESH] |COVID-19/*immunology/virology[MESH] |Cells, Cultured[MESH] |Dendritic Cells/immunology[MESH] |Female[MESH] |Humans[MESH] |Inflammation/*immunology[MESH] |Lymphocyte Activation/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Monocytes/immunology[MESH] |Neutrophils/immunology[MESH] |Pneumonia/*immunology[MESH] |SARS-CoV-2/*immunology/physiology[MESH] |T-Lymphocytes/*immunology[MESH]Severe T cell hyporeactivity in ventilated COVID-19 patients correlate(epmc).pdf DeepDyve Pubget Overpricing