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10.1186/s12931-021-01750-8

http://scihub22266oqcxt.onion/10.1186/s12931-021-01750-8
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34020644!8139368!34020644
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suck abstract from ncbi


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pmid34020644      Respir+Res 2021 ; 22 (1): 157
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  • Risk factors for persistent abnormality on chest radiographs at 12-weeks post hospitalisation with PCR confirmed COVID-19 #MMPMID34020644
  • Wallis TJM; Heiden E; Horno J; Welham B; Burke H; Freeman A; Dexter L; Fazleen A; Kong A; McQuitty C; Watson M; Poole S; Brendish NJ; Clark TW; Wilkinson TMA; Jones MG; Marshall BG
  • Respir Res 2021[May]; 22 (1): 157 PMID34020644show ga
  • BACKGROUND: The long-term consequences of COVID-19 remain unclear. There is concern a proportion of patients will progress to develop pulmonary fibrosis. We aimed to assess the temporal change in CXR infiltrates in a cohort of patients following hospitalisation for COVID-19. METHODS: We conducted a single-centre prospective cohort study of patients admitted to University Hospital Southampton with confirmed SARS-CoV2 infection between 20th March and 3rd June 2020. Patients were approached for standard-of-care follow-up 12-weeks after hospitalisation. Inpatient and follow-up CXRs were scored by the assessing clinician for extent of pulmonary infiltrates; 0-4 per lung (Nil = 0, < 25% = 1, 25-50% = 2, 51-75% = 3, > 75% = 4). RESULTS: 101 patients with paired CXRs were included. Demographics: 53% male with a median (IQR) age 53.0 (45-63) years and length of stay 9 (5-17.5) days. The median CXR follow-up interval was 82 (77-86) days with median baseline and follow-up CXR scores of 4.0 (3-5) and 0.0 (0-1) respectively. 32% of patients had persistent CXR abnormality at 12-weeks. In multivariate analysis length of stay (LOS), smoking-status and obesity were identified as independent risk factors for persistent CXR abnormality. Serum LDH was significantly higher at baseline and at follow-up in patients with CXR abnormalities compared to those with resolution. A 5-point composite risk score (1-point each; LOS >/= 15 days, Level 2/3 admission, LDH > 750 U/L, obesity and smoking-status) strongly predicted risk of persistent radiograph abnormality (0.81). CONCLUSION: Persistent CXR abnormality 12-weeks post COVID-19 was common in this cohort. LOS, obesity, increased serum LDH, and smoking-status were risk factors for radiograph abnormality. These findings require further prospective validation.
  • |Aged[MESH]
  • |COVID-19/*complications/*diagnostic imaging[MESH]
  • |Cohort Studies[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |L-Lactate Dehydrogenase/blood[MESH]
  • |Length of Stay[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Obesity[MESH]
  • |Polymerase Chain Reaction[MESH]
  • |Prospective Studies[MESH]
  • |Radiography, Thoracic[MESH]
  • |Risk Factors[MESH]
  • |Smoking[MESH]
  • |Thorax/*diagnostic imaging[MESH]


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