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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Int+Immunopharmacol 2021 ; 96 (ä): 107777 Nephropedia Template TP
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Insights on the mechanisms of action of ozone in the medical therapy against COVID-19 #MMPMID34020394
Chirumbolo S; Valdenassi L; Simonetti V; Bertossi D; Ricevuti G; Franzini M; Pandolfi S
Int Immunopharmacol 2021[Jul]; 96 (ä): 107777 PMID34020394show ga
An increasing amount of reports in the literature is showing that medical ozone (O(3)) is used, with encouraging results, in treating COVID-19 patients, optimizing pain and symptoms relief, respiratory parameters, inflammatory and coagulation markers and the overall health status, so reducing significantly how much time patients underwent hospitalization and intensive care. To date, aside from mechanisms taking into account the ability of O(3) to activate a rapid oxidative stress response, by up-regulating antioxidant and scavenging enzymes, no sound hypothesis was addressed to attempt a synopsis of how O(3) should act on COVID-19. The knowledge on how O(3) works on inflammation and thrombosis mechanisms is of the utmost importance to make physicians endowed with new guns against SARS-CoV2 pandemic. This review tries to address this issue, so to expand the debate in the scientific community.