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10.1016/j.cell.2021.04.042 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.04.042 34019795!8135257!34019795     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (11): 2955-2972.e25 Nephropedia Template TP {{tp|p=34019795|t=2021. Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies |pdf=|usr=}}{{34019795}} gab.com Text Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=34019795 #FOAvip Natural antibodies (Abs) can target host glycans on the surface of pathogens. We studied the evolution of glycan-reactive B cells of rhesus macaques and humans using glycosylated HIV-1 envelope (Env) as a model antigen. 2G12 is a broadly neutralizing Ab (bnAb) that targets a conserved glycan patch on Env of geographically diverse HIV-1 strains using a unique heavy-chain (V(H)) domain-swapped architecture that results in fragment antigen-binding (Fab) dimerization. Here, we describe HIV-1 Env Fab-dimerized glycan (FDG)-reactive bnAbs without V(H)-swapped domains from simian-human immunodeficiency virus (SHIV)-infected macaques. FDG Abs also recognized cell-surface glycans on diverse pathogens, including yeast and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike. FDG precursors were expanded by glycan-bearing immunogens in macaques and were abundant in HIV-1-naive humans. Moreover, FDG precursors were predominately mutated IgM(+)IgD(+)CD27(+), thus suggesting that they originated from a pool of antigen-experienced IgM(+) or marginal zone B cells. Twit Text FOAVip Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=34019795 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34019795 #FOAvip English Wikipedia <ref>{{Cite pmid|34019795}}</ref> Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies #MMPMID34019795 Williams WB; Meyerhoff RR; Edwards RJ; Li H; Manne K; Nicely NI; Henderson R; Zhou Y; Janowska K; Mansouri K; Gobeil S; Evangelous T; Hora B; Berry M; Abuahmad AY; Sprenz J; Deyton M; Stalls V; Kopp M; Hsu AL; Borgnia MJ; Stewart-Jones GBE; Lee MS; Bronkema N; Moody MA; Wiehe K; Bradley T; Alam SM; Parks RJ; Foulger A; Oguin T; Sempowski GD; Bonsignori M; LaBranche CC; Montefiori DC; Seaman M; Santra S; Perfect J; Francica JR; Lynn GM; Aussedat B; Walkowicz WE; Laga R; Kelsoe G; Saunders KO; Fera D; Kwong PD; Seder RA; Bartesaghi A; Shaw GM; Acharya P; Haynes BF Cell 2021[May]; 184 (11): 2955-2972.e25 PMID34019795show ga Natural antibodies (Abs) can target host glycans on the surface of pathogens. We studied the evolution of glycan-reactive B cells of rhesus macaques and humans using glycosylated HIV-1 envelope (Env) as a model antigen. 2G12 is a broadly neutralizing Ab (bnAb) that targets a conserved glycan patch on Env of geographically diverse HIV-1 strains using a unique heavy-chain (V(H)) domain-swapped architecture that results in fragment antigen-binding (Fab) dimerization. Here, we describe HIV-1 Env Fab-dimerized glycan (FDG)-reactive bnAbs without V(H)-swapped domains from simian-human immunodeficiency virus (SHIV)-infected macaques. FDG Abs also recognized cell-surface glycans on diverse pathogens, including yeast and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike. FDG precursors were expanded by glycan-bearing immunogens in macaques and were abundant in HIV-1-naive humans. Moreover, FDG precursors were predominately mutated IgM(+)IgD(+)CD27(+), thus suggesting that they originated from a pool of antigen-experienced IgM(+) or marginal zone B cells. |Animals[MESH] |Antibodies, Neutralizing/*immunology[MESH] |B-Lymphocytes/immunology[MESH] |Broadly Neutralizing Antibodies/immunology[MESH] |COVID-19/immunology[MESH] |Dimerization[MESH] |Epitopes/immunology[MESH] |Glycosylation[MESH] |HIV Antibodies/immunology[MESH] |HIV Infections/immunology[MESH] |HIV-1/*immunology[MESH] |Humans[MESH] |Immunoglobulin Fab Fragments/chemistry/*immunology[MESH] |Macaca mulatta[MESH] |Polysaccharides/chemistry/*immunology[MESH] |Receptors, Antigen, B-Cell/chemistry[MESH] |SARS-CoV-2/*immunology[MESH] |Simian Immunodeficiency Virus/genetics/*immunology[MESH] |Spike Glycoprotein, Coronavirus/*immunology[MESH] |Vaccines/immunology[MESH]Fab-dimerized glycan-reactive antibodies are a structural category of (epmc).pdf DeepDyve Pubget Overpricing