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10.3389/fphar.2021.660710 http://scihub22266oqcxt.onion/10.3389/fphar.2021.660710 34017257!8129523!34017257     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Pharmacol 2021 ; 12 (ä): 660710 Nephropedia Template TP {{tp|p=34017257|t=2021. Strategy, Progress, and Challenges of Drug Repurposing for Efficient Antiviral Discovery |pdf=|usr=}}{{34017257}} gab.com Text Strategy, Progress, and Challenges of Drug Repurposing for Efficient Antiviral Discovery JO: Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34017257 #FOAvip Emerging or re-emerging viruses are still major threats to public health. Prophylactic vaccines represent the most effective way to prevent virus infection; however, antivirals are more promising for those viruses against which vaccines are not effective enough or contemporarily unavailable. Because of the slow pace of novel antiviral discovery, the high disuse rates, and the substantial cost, repurposing of the well-characterized therapeutics, either approved or under investigation, is becoming an attractive strategy to identify the new directions to treat virus infections. In this review, we described recent progress in identifying broad-spectrum antivirals through drug repurposing. We defined the two major categories of the repurposed antivirals, direct-acting repurposed antivirals (DARA) and host-targeting repurposed antivirals (HTRA). Under each category, we summarized repurposed antivirals with potential broad-spectrum activity against a variety of viruses and discussed the possible mechanisms of action. Finally, we proposed the potential investigative directions of drug repurposing. Twit Text FOAVip Strategy, Progress, and Challenges of Drug Repurposing for Efficient Antiviral Discovery ????Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34017257 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34017257 #FOAvip English Wikipedia <ref>{{Cite pmid|34017257}}</ref> Strategy, Progress, and Challenges of Drug Repurposing for Efficient Antiviral Discovery #MMPMID34017257 Li X; Peng T Front Pharmacol 2021[]; 12 (ä): 660710 PMID34017257show ga Emerging or re-emerging viruses are still major threats to public health. Prophylactic vaccines represent the most effective way to prevent virus infection; however, antivirals are more promising for those viruses against which vaccines are not effective enough or contemporarily unavailable. Because of the slow pace of novel antiviral discovery, the high disuse rates, and the substantial cost, repurposing of the well-characterized therapeutics, either approved or under investigation, is becoming an attractive strategy to identify the new directions to treat virus infections. In this review, we described recent progress in identifying broad-spectrum antivirals through drug repurposing. We defined the two major categories of the repurposed antivirals, direct-acting repurposed antivirals (DARA) and host-targeting repurposed antivirals (HTRA). Under each category, we summarized repurposed antivirals with potential broad-spectrum activity against a variety of viruses and discussed the possible mechanisms of action. Finally, we proposed the potential investigative directions of drug repurposing. äStrategy, Progress, and Challenges of Drug Repurposing for Efficient A(epmc).pdf DeepDyve Pubget Overpricing