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10.1038/s41598-021-90243-1 http://scihub22266oqcxt.onion/10.1038/s41598-021-90243-1 34017039!8138024!34017039     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 10629 Nephropedia Template TP {{tp|p=34017039|t=2021. Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection |pdf=|usr=}}{{34017039}} gab.com Text Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34017039 #FOAvip Delirium is an acute change in attention and cognition occurring in ~ 65% of severe SARS-CoV-2 cases. It is also common following surgery and an indicator of brain vulnerability and risk for the development of dementia. In this work we analyzed the underlying role of metabolism in delirium-susceptibility in the postoperative setting using metabolomic profiling of cerebrospinal fluid and blood taken from the same patients prior to planned orthopaedic surgery. Distance correlation analysis and Random Forest (RF) feature selection were used to determine changes in metabolic networks. We found significant concentration differences in several amino acids, acylcarnitines and polyamines linking delirium-prone patients to known factors in Alzheimer's disease such as monoamine oxidase B (MAOB) protein. Subsequent computational structural comparison between MAOB and angiotensin converting enzyme 2 as well as protein-protein docking analysis showed that there potentially is strong binding of SARS-CoV-2 spike protein to MAOB. The possibility that SARS-CoV-2 influences MAOB activity leading to the observed neurological and platelet-based complications of SARS-CoV-2 infection requires further investigation. Twit Text FOAVip Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34017039 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34017039 #FOAvip English Wikipedia <ref>{{Cite pmid|34017039}}</ref> Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection #MMPMID34017039 Cuperlovic-Culf M; Cunningham EL; Teimoorinia H; Surendra A; Pan X; Bennett SAL; Jung M; McGuiness B; Passmore AP; Beverland D; Green BD Sci Rep 2021[May]; 11 (1): 10629 PMID34017039show ga Delirium is an acute change in attention and cognition occurring in ~ 65% of severe SARS-CoV-2 cases. It is also common following surgery and an indicator of brain vulnerability and risk for the development of dementia. In this work we analyzed the underlying role of metabolism in delirium-susceptibility in the postoperative setting using metabolomic profiling of cerebrospinal fluid and blood taken from the same patients prior to planned orthopaedic surgery. Distance correlation analysis and Random Forest (RF) feature selection were used to determine changes in metabolic networks. We found significant concentration differences in several amino acids, acylcarnitines and polyamines linking delirium-prone patients to known factors in Alzheimer's disease such as monoamine oxidase B (MAOB) protein. Subsequent computational structural comparison between MAOB and angiotensin converting enzyme 2 as well as protein-protein docking analysis showed that there potentially is strong binding of SARS-CoV-2 spike protein to MAOB. The possibility that SARS-CoV-2 influences MAOB activity leading to the observed neurological and platelet-based complications of SARS-CoV-2 infection requires further investigation. |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/*metabolism[MESH] |Delirium/*metabolism[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Metabolomics[MESH] |Monoamine Oxidase/*metabolism[MESH]Metabolomics and computational analysis of the role of monoamine oxida(epmc).pdf DeepDyve Pubget Overpricing