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10.1038/s42003-021-02127-9 http://scihub22266oqcxt.onion/10.1038/s42003-021-02127-9 34017036!8137958!34017036     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Commun+Biol 2021 ; 4 (1): 599 Nephropedia Template TP {{tp|p=34017036|t=2021. TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel |pdf=|usr=}}{{34017036}} gab.com Text TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel JO: Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=34017036 #FOAvip Animal cells can regulate their volume after swelling by the regulatory volume decrease (RVD) mechanism. In epithelial cells, RVD is attained through KCl release mediated via volume-sensitive outwardly rectifying Cl(-) channels (VSOR) and Ca(2+)-activated K(+) channels. Swelling-induced activation of TRPM7 cation channels leads to Ca(2+) influx, thereby stimulating the K(+) channels. Here, we examined whether TRPM7 plays any role in VSOR activation. When TRPM7 was knocked down in human HeLa cells or knocked out in chicken DT40 cells, not only TRPM7 activity and RVD efficacy but also VSOR activity were suppressed. Heterologous expression of TRPM7 in TRPM7-deficient DT40 cells rescued both VSOR activity and RVD, accompanied by an increase in the expression of LRRC8A, a core molecule of VSOR. TRPM7 exerts the facilitating action on VSOR activity first by enhancing molecular expression of LRRC8A mRNA through the mediation of steady-state Ca(2+) influx and second by stabilizing the plasmalemmal expression of LRRC8A protein through the interaction between LRRC8A and the C-terminal domain of TRPM7. Therefore, TRPM7 functions as an essential regulator of VSOR activity and LRRC8A expression. Twit Text FOAVip TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel ????Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=34017036 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34017036 #FOAvip English Wikipedia <ref>{{Cite pmid|34017036}}</ref> TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel #MMPMID34017036 Numata T; Sato-Numata K; Hermosura MC; Mori Y; Okada Y Commun Biol 2021[May]; 4 (1): 599 PMID34017036show ga Animal cells can regulate their volume after swelling by the regulatory volume decrease (RVD) mechanism. In epithelial cells, RVD is attained through KCl release mediated via volume-sensitive outwardly rectifying Cl(-) channels (VSOR) and Ca(2+)-activated K(+) channels. Swelling-induced activation of TRPM7 cation channels leads to Ca(2+) influx, thereby stimulating the K(+) channels. Here, we examined whether TRPM7 plays any role in VSOR activation. When TRPM7 was knocked down in human HeLa cells or knocked out in chicken DT40 cells, not only TRPM7 activity and RVD efficacy but also VSOR activity were suppressed. Heterologous expression of TRPM7 in TRPM7-deficient DT40 cells rescued both VSOR activity and RVD, accompanied by an increase in the expression of LRRC8A, a core molecule of VSOR. TRPM7 exerts the facilitating action on VSOR activity first by enhancing molecular expression of LRRC8A mRNA through the mediation of steady-state Ca(2+) influx and second by stabilizing the plasmalemmal expression of LRRC8A protein through the interaction between LRRC8A and the C-terminal domain of TRPM7. Therefore, TRPM7 functions as an essential regulator of VSOR activity and LRRC8A expression. |*Ion Channel Gating[MESH] |Animals[MESH] |Anions/*metabolism[MESH] |Calcium/*metabolism[MESH] |Cells, Cultured[MESH] |Chickens[MESH] |Epithelial Cells/cytology/*metabolism[MESH] |HeLa Cells[MESH] |Humans[MESH] |Ion Channels/genetics/*metabolism[MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism[MESH]TRPM7 is an essential regulator for volume-sensitive outwardly rectify(epmc).pdf DeepDyve Pubget Overpricing