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10.1080/14787210.2021.1933437 http://scihub22266oqcxt.onion/10.1080/14787210.2021.1933437 34015985!8171006!34015985     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Expert+Rev+Anti+Infect+Ther 2021 ; 19 (12): 1553-1562 Nephropedia Template TP {{tp|p=34015985|t=2021. Corticosteroids in SARS-COV2 infection: certainties and uncertainties in clinical practice |pdf=|usr=}}{{34015985}} gab.com Text Corticosteroids in SARS-COV2 infection: certainties and uncertainties in clinical practice JO: Expert Rev Anti Infect Ther http://www.kidney.de/pget.php?&tw=1&pmid=34015985 #FOAvip INTRODUCTION: The SARS-COV-2 pandemic is a worldwide public health problem due to the large medical burden and limited number of therapies available. Corticosteroids have a rather unclear efficacy in viral non-SARS-COV-2 pneumonias and therefore their use is not universally recommended. In SARS-COV-2 pneumonia however, it is expected that they can reduce the deleterious consequences of the virus-related systemic inflammation. AREAS COVERED: a MEDLINE search covering the period 1995-2020 was completed to identify relevant papers. SARS-COV-2 pathogenesis is very complex and is represented by the interplay of many cytokine-driven inflammation pathways. Its most severe form so called cytokine storm, is an exaggerate reaction of the host infected by the virus rapidly resulting in multiple organ dysfunction (MODS). Corticosteroids have the potential to blunt the inflammation response in such patients, but their efficacy is not the same for all patients. Further on the certainties and uncertainties regarding the efficacy of this therapy in SARS-COV-2 pneumonia are discussed. EXPERT OPINION: In patients with severe SARS-COV-2 pneumonia, corticosteroids can be efficacious, but it is still not clear if they can be safely used in patients with comorbid cardiovascular disease or how the optimal duration of therapy can be established. Twit Text FOAVip Corticosteroids in SARS-COV2 infection: certainties and uncertainties in clinical practice ????Expert Rev Anti Infect Ther http://www.kidney.de/pget.php?&tw=1&pmid=34015985 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34015985 #FOAvip English Wikipedia <ref>{{Cite pmid|34015985}}</ref> Corticosteroids in SARS-COV2 infection: certainties and uncertainties in clinical practice #MMPMID34015985 Crisan Dabija R; Antohe I; Trofor A; Antoniu SA Expert Rev Anti Infect Ther 2021[Dec]; 19 (12): 1553-1562 PMID34015985show ga INTRODUCTION: The SARS-COV-2 pandemic is a worldwide public health problem due to the large medical burden and limited number of therapies available. Corticosteroids have a rather unclear efficacy in viral non-SARS-COV-2 pneumonias and therefore their use is not universally recommended. In SARS-COV-2 pneumonia however, it is expected that they can reduce the deleterious consequences of the virus-related systemic inflammation. AREAS COVERED: a MEDLINE search covering the period 1995-2020 was completed to identify relevant papers. SARS-COV-2 pathogenesis is very complex and is represented by the interplay of many cytokine-driven inflammation pathways. Its most severe form so called cytokine storm, is an exaggerate reaction of the host infected by the virus rapidly resulting in multiple organ dysfunction (MODS). Corticosteroids have the potential to blunt the inflammation response in such patients, but their efficacy is not the same for all patients. Further on the certainties and uncertainties regarding the efficacy of this therapy in SARS-COV-2 pneumonia are discussed. EXPERT OPINION: In patients with severe SARS-COV-2 pneumonia, corticosteroids can be efficacious, but it is still not clear if they can be safely used in patients with comorbid cardiovascular disease or how the optimal duration of therapy can be established. |*COVID-19 Drug Treatment[MESH] |Adrenal Cortex Hormones/*therapeutic use[MESH] |Adult[MESH] |Aged[MESH] |COVID-19/diagnosis/mortality[MESH] |Dexamethasone/*therapeutic use[MESH] |Female[MESH] |Humans[MESH] |Inflammation[MESH] |Male[MESH] |Methylprednisolone/*therapeutic use[MESH] |Middle Aged[MESH] |Pneumonia, Viral/*drug therapy[MESH] |RNA, Viral[MESH]Corticosteroids in SARS-COV2 infection: certainties and uncertainties (epmc).pdf DeepDyve Pubget Overpricing