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10.1080/14737159.2021.1933449

http://scihub22266oqcxt.onion/10.1080/14737159.2021.1933449
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suck abstract from ncbi


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pmid34015984      Expert+Rev+Mol+Diagn 2021 ; 21 (7): 733-740
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  • The diagnostic accuracy of seven commercial molecular in vitro SARS-CoV-2 detection tests: a rapid meta-analysis #MMPMID34015984
  • Ulhaq ZS; Soraya GV
  • Expert Rev Mol Diagn 2021[Jul]; 21 (7): 733-740 PMID34015984show ga
  • OBJECTIVE: To compare the accuracy parameters of seven commercial molecular in vitro diagnostic tests for detecting SARS-CoV-2. METHODS: Studies evaluating the accuracy of seven different commercial molecular diagnostic tests for detecting SARS-CoV-2 (Cepheid Xpert Xpress SARS-CoV-2 test, Simplexa COVID-19 Direct, Abbott ID NOW COVID-19, Cobas SARS-CoV-2, Allplex 2019-nCoV Assay, Panther Fusion SARS-CoV-2, and BioFire COVID-19 Test) were included. The quality of the included studies was assessed using the QUADAS-2 checklist. A bivariate random-effects regression model was implemented. RESULTS: Meta-analysis of 12 included studies showed that the performances of commercial COVID-19 molecular in vitro diagnostic tests were high, with a summary sensitivity of 95.9% (95% CI 93.9-97.2%, I(2) = 60.22%) and specificity of 97.2% (95% CI 95.5-98.3%, I(2) = 56.66%). Among seven evaluated tests, the Abbott ID NOW COVID-19 and Simplexa COVID-19 Direct displayed lower sensitivity (91.6%, 95% CI 80.5-96.6% and 92%, 95% CI 86.2-95.5, respectively). CONCLUSION: All evaluated tests showed good accuracy. However, the slightly lower sensitivity observed in the Abbott ID Now COVID-19 and Simplexa COVID-19 Direct should be considered when deciding on a test platform. Moreover, the diagnostic accuracy of COVID-19 commercial diagnostic tests should be weighed against their ease of use and speed.
  • |*COVID-19 Testing[MESH]
  • |*SARS-CoV-2[MESH]
  • |COVID-19/*diagnosis[MESH]
  • |Humans[MESH]


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