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10.1093/bib/bbab192 http://scihub22266oqcxt.onion/10.1093/bib/bbab192 34015809!8194558!34015809     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brief+Bioinform 2021 ; 22 (6): ä Nephropedia Template TP {{tp|p=34015809|t=2021. Global characterization of B cell receptor repertoire in COVID-19 patients by single-cell V(D)J sequencing |pdf=|usr=}}{{34015809}} gab.com Text Global characterization of B cell receptor repertoire in COVID-19 patients by single-cell V(D)J sequencing JO: Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=34015809 #FOAvip The world is facing a pandemic of Corona Virus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Adaptive immune responses are essential for SARS-CoV-2 virus clearance. Although a large body of studies have been conducted to investigate the immune mechanism in COVID-19 patients, we still lack a comprehensive understanding of the BCR repertoire in patients. In this study, we used the single-cell V(D)J sequencing to characterize the BCR repertoire across convalescent COVID-19 patients. We observed that the BCR diversity was significantly reduced in disease compared with healthy controls. And BCRs tend to skew toward different V gene segments in COVID-19 and healthy controls. The CDR3 sequences of heavy chain in clonal BCRs in patients were more convergent than that in healthy controls. In addition, we discovered increased IgG and IgA isotypes in the disease, including IgG1, IgG3 and IgA1. In all clonal BCRs, IgG isotypes had the most frequent class switch recombination events and the highest somatic hypermutation rate, especially IgG3. Moreover, we found that an IgG3 cluster from different clonal groups had the same IGHV, IGHJ and CDR3 sequences (IGHV4-4-CARLANTNQFYDSSSYLNAMDVW-IGHJ6). Overall, our study provides a comprehensive characterization of the BCR repertoire in COVID-19 patients, which contributes to the understanding of the mechanism for the immune response to SARS-CoV-2 infection. Twit Text FOAVip Global characterization of B cell receptor repertoire in COVID-19 patients by single-cell V(D)J sequencing ????Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=34015809 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34015809 #FOAvip English Wikipedia <ref>{{Cite pmid|34015809}}</ref> Global characterization of B cell receptor repertoire in COVID-19 patients by single-cell V(D)J sequencing #MMPMID34015809 Jin X; Zhou W; Luo M; Wang P; Xu Z; Ma K; Cao H; Xu C; Huang Y; Cheng R; Xiao L; Lin X; Pang F; Li Y; Nie H; Jiang Q Brief Bioinform 2021[Nov]; 22 (6): ä PMID34015809show ga The world is facing a pandemic of Corona Virus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Adaptive immune responses are essential for SARS-CoV-2 virus clearance. Although a large body of studies have been conducted to investigate the immune mechanism in COVID-19 patients, we still lack a comprehensive understanding of the BCR repertoire in patients. In this study, we used the single-cell V(D)J sequencing to characterize the BCR repertoire across convalescent COVID-19 patients. We observed that the BCR diversity was significantly reduced in disease compared with healthy controls. And BCRs tend to skew toward different V gene segments in COVID-19 and healthy controls. The CDR3 sequences of heavy chain in clonal BCRs in patients were more convergent than that in healthy controls. In addition, we discovered increased IgG and IgA isotypes in the disease, including IgG1, IgG3 and IgA1. In all clonal BCRs, IgG isotypes had the most frequent class switch recombination events and the highest somatic hypermutation rate, especially IgG3. Moreover, we found that an IgG3 cluster from different clonal groups had the same IGHV, IGHJ and CDR3 sequences (IGHV4-4-CARLANTNQFYDSSSYLNAMDVW-IGHJ6). Overall, our study provides a comprehensive characterization of the BCR repertoire in COVID-19 patients, which contributes to the understanding of the mechanism for the immune response to SARS-CoV-2 infection. |B-Lymphocytes/immunology[MESH] |COVID-19/genetics/*immunology/virology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin A/genetics/immunology[MESH] |Immunoglobulin G/genetics/immunology[MESH] |Male[MESH] |Receptors, Antigen, B-Cell/*genetics/immunology[MESH] |SARS-CoV-2/*immunology/pathogenicity[MESH] |Sequence Analysis[MESH] |Single-Cell Analysis[MESH]Global characterization of B cell receptor repertoire in COVID-19 pati(epmc).pdf DeepDyve Pubget Overpricing