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10.1016/j.carres.2021.108326 http://scihub22266oqcxt.onion/10.1016/j.carres.2021.108326 34015720!8091805!34015720     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Carbohydr+Res 2021 ; 505 (ä): 108326 Nephropedia Template TP {{tp|p=34015720|t=2021. Marine sulfated polysaccharides as potential antiviral drug candidates to treat Corona Virus disease (COVID-19) |pdf=|usr=}}{{34015720}} gab.com Text Marine sulfated polysaccharides as potential antiviral drug candidates to treat Corona Virus disease (COVID-19) JO: Carbohydr Res http://www.kidney.de/pget.php?&tw=1&pmid=34015720 #FOAvip The viral infection caused by SARS-CoV-2 has increased the mortality rate and engaged several adverse effects on the affected individuals. Currently available antiviral drugs have found to be unsuccessful in the treatment of COVID-19 patients. The demand for efficient antiviral drugs has created a huge burden on physicians and health workers. Plasma therapy seems to be less accomplishable due to insufficient donors to donate plasma and low recovery rate from viral infection. Repurposing of antivirals has been evolved as a suitable strategy in the current treatment and preventive measures. The concept of drug repurposing represents new experimental approaches for effective therapeutic benefits. Besides, SARS-CoV-2 exhibits several complications such as lung damage, blood clot formation, respiratory illness and organ failures in most of the patients. Based on the accumulation of data, sulfated marine polysaccharides have exerted successful inhibition of virus entry, attachment and replication with known or unknown possible mechanisms against deadly animal and human viruses so far. Since the virus entry into the host cells is the key process, the prevention of such entry mechanism makes any antiviral strategy effective. Enveloped viruses are more sensitive to polyanions than non-enveloped viruses. Besides, the viral infection caused by RNA virus types embarks severe oxidative stress in the human body that leads to malfunction of tissues and organs. In this context, polysaccharides play a very significant role in providing shielding effect against the virus due to their polyanionic rich features and a molecular weight that hinders their reactive surface glycoproteins. Significantly the functional groups especially sulfate, sulfate pattern and addition, uronic acids, monosaccharides, glycosidic linkage and high molecular weight have greater influence in the antiviral activity. Moreover, they are very good antioxidants that can reduce the free radical generation and provokes intracellular antioxidant enzymes. Additionally, polysaccharides enable a host-virus immune response, activate phagocytosis and stimulate interferon systems. Therefore, polysaccharides can be used as candidate drugs, adjuvants in vaccines or combination with other antivirals, antioxidants and immune-activating nutritional supplements and antiviral materials in healthcare products to prevent SARS-CoV-2 infection. Twit Text FOAVip Marine sulfated polysaccharides as potential antiviral drug candidates to treat Corona Virus disease (COVID-19) ????Carbohydr Res http://www.kidney.de/pget.php?&tw=1&pmid=34015720 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34015720 #FOAvip English Wikipedia <ref>{{Cite pmid|34015720}}</ref> Marine sulfated polysaccharides as potential antiviral drug candidates to treat Corona Virus disease (COVID-19) #MMPMID34015720 Andrew M; Jayaraman G Carbohydr Res 2021[Jul]; 505 (ä): 108326 PMID34015720show ga The viral infection caused by SARS-CoV-2 has increased the mortality rate and engaged several adverse effects on the affected individuals. Currently available antiviral drugs have found to be unsuccessful in the treatment of COVID-19 patients. The demand for efficient antiviral drugs has created a huge burden on physicians and health workers. Plasma therapy seems to be less accomplishable due to insufficient donors to donate plasma and low recovery rate from viral infection. Repurposing of antivirals has been evolved as a suitable strategy in the current treatment and preventive measures. The concept of drug repurposing represents new experimental approaches for effective therapeutic benefits. Besides, SARS-CoV-2 exhibits several complications such as lung damage, blood clot formation, respiratory illness and organ failures in most of the patients. Based on the accumulation of data, sulfated marine polysaccharides have exerted successful inhibition of virus entry, attachment and replication with known or unknown possible mechanisms against deadly animal and human viruses so far. Since the virus entry into the host cells is the key process, the prevention of such entry mechanism makes any antiviral strategy effective. Enveloped viruses are more sensitive to polyanions than non-enveloped viruses. Besides, the viral infection caused by RNA virus types embarks severe oxidative stress in the human body that leads to malfunction of tissues and organs. In this context, polysaccharides play a very significant role in providing shielding effect against the virus due to their polyanionic rich features and a molecular weight that hinders their reactive surface glycoproteins. Significantly the functional groups especially sulfate, sulfate pattern and addition, uronic acids, monosaccharides, glycosidic linkage and high molecular weight have greater influence in the antiviral activity. Moreover, they are very good antioxidants that can reduce the free radical generation and provokes intracellular antioxidant enzymes. Additionally, polysaccharides enable a host-virus immune response, activate phagocytosis and stimulate interferon systems. Therefore, polysaccharides can be used as candidate drugs, adjuvants in vaccines or combination with other antivirals, antioxidants and immune-activating nutritional supplements and antiviral materials in healthcare products to prevent SARS-CoV-2 infection. |*COVID-19 Drug Treatment[MESH] |Anticoagulants/chemistry/isolation & purification/*therapeutic use[MESH] |Antiviral Agents/chemistry/isolation & purification/*therapeutic use[MESH] |Blood Platelets/drug effects/pathology/virology[MESH] |COVID-19/complications/diagnosis/virology[MESH] |Humans[MESH] |Immunologic Factors/chemistry/isolation & purification/*therapeutic use[MESH] |Lung/blood supply/drug effects/pathology/virology[MESH] |Phaeophyceae/chemistry[MESH] |Polysaccharides/chemistry/isolation & purification/*therapeutic use[MESH] |Pulmonary Embolism/complications/diagnosis/*drug therapy/virology[MESH] |Respiratory Insufficiency/complications/diagnosis/*drug therapy/virology[MESH] |Rhodophyta/chemistry[MESH] |SARS-CoV-2/drug effects/pathogenicity[MESH] |Sulfuric Acid Esters/chemistry[MESH] |Virus Attachment/drug effects[MESH]Marine sulfated polysaccharides as potential antiviral drug candidates(epmc).pdf DeepDyve Pubget Overpricing