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10.1371/journal.ppat.1009576

http://scihub22266oqcxt.onion/10.1371/journal.ppat.1009576
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34015061!8136665!34015061
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suck abstract from ncbi


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pmid34015061      PLoS+Pathog 2021 ; 17 (5): e1009576
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  • DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist #MMPMID34015061
  • Thepaut M; Luczkowiak J; Vives C; Labiod N; Bally I; Lasala F; Grimoire Y; Fenel D; Sattin S; Thielens N; Schoehn G; Bernardi A; Delgado R; Fieschi F
  • PLoS Pathog 2021[May]; 17 (5): e1009576 PMID34015061show ga
  • The efficient spread of SARS-CoV-2 resulted in a unique pandemic in modern history. Despite early identification of ACE2 as the receptor for viral spike protein, much remains to be understood about the molecular events behind viral dissemination. We evaluated the contribution of C-type lectin receptors (CLRS) of antigen-presenting cells, widely present in respiratory mucosa and lung tissue. DC-SIGN, L-SIGN, Langerin and MGL bind to diverse glycans of the spike using multiple interaction areas. Using pseudovirus and cells derived from monocytes or T-lymphocytes, we demonstrate that while virus capture by the CLRs examined does not allow direct cell infection, DC/L-SIGN, among these receptors, promote virus transfer to permissive ACE2+ Vero E6 cells. A glycomimetic compound designed against DC-SIGN, enable inhibition of this process. These data have been then confirmed using authentic SARS-CoV-2 virus and human respiratory cell lines. Thus, we described a mechanism potentiating viral spreading of infection.
  • |Animals[MESH]
  • |Antigens, CD/metabolism[MESH]
  • |COVID-19/prevention & control/*transmission[MESH]
  • |Cell Adhesion Molecules/metabolism[MESH]
  • |Cell Line[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Humans[MESH]
  • |Jurkat Cells[MESH]
  • |Lectins, C-Type/*metabolism[MESH]
  • |Lung/metabolism[MESH]
  • |Mannose-Binding Lectins/metabolism[MESH]
  • |Mannosides/pharmacology[MESH]
  • |Protein Binding/drug effects[MESH]
  • |Receptors, Cell Surface/metabolism[MESH]
  • |Respiratory Mucosa/metabolism[MESH]
  • |SARS-CoV-2/*metabolism[MESH]
  • |Spike Glycoprotein, Coronavirus/*metabolism[MESH]


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