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10.15585/mmwr.mm7020e2

http://scihub22266oqcxt.onion/10.15585/mmwr.mm7020e2
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34014909!8136422!34014909
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suck abstract from ncbi


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pmid34014909      MMWR+Morb+Mortal+Wkly+Rep 2021 ; 70 (20): 753-758
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  • Interim Estimates of Vaccine Effectiveness of Pfizer-BioNTech and Moderna COVID-19 Vaccines Among Health Care Personnel - 33 U S Sites, January-March 2021 #MMPMID34014909
  • Pilishvili T; Fleming-Dutra KE; Farrar JL; Gierke R; Mohr NM; Talan DA; Krishnadasan A; Harland KK; Smithline HA; Hou PC; Lee LC; Lim SC; Moran GJ; Krebs E; Steele M; Beiser DG; Faine B; Haran JP; Nandi U; Schrading WA; Chinnock B; Henning DJ; LoVecchio F; Nadle J; Barter D; Brackney M; Britton A; Marceaux-Galli K; Lim S; Phipps EC; Dumyati G; Pierce R; Markus TM; Anderson DJ; Debes AK; Lin M; Mayer J; Babcock HM; Safdar N; Fischer M; Singleton R; Chea N; Magill SS; Verani J; Schrag S
  • MMWR Morb Mortal Wkly Rep 2021[May]; 70 (20): 753-758 PMID34014909show ga
  • Throughout the COVID-19 pandemic, health care personnel (HCP) have been at high risk for exposure to SARS-CoV-2, the virus that causes COVID-19, through patient interactions and community exposure (1). The Advisory Committee on Immunization Practices recommended prioritization of HCP for COVID-19 vaccination to maintain provision of critical services and reduce spread of infection in health care settings (2). Early distribution of two mRNA COVID-19 vaccines (Pfizer-BioNTech and Moderna) to HCP allowed assessment of the effectiveness of these vaccines in a real-world setting. A test-negative case-control study is underway to evaluate mRNA COVID-19 vaccine effectiveness (VE) against symptomatic illness among HCP at 33 U.S. sites across 25 U.S. states. Interim analyses indicated that the VE of a single dose (measured 14 days after the first dose through 6 days after the second dose) was 82% (95% confidence interval [CI] = 74%-87%), adjusted for age, race/ethnicity, and underlying medical conditions. The adjusted VE of 2 doses (measured >/=7 days after the second dose) was 94% (95% CI = 87%-97%). VE of partial (1-dose) and complete (2-dose) vaccination in this population is comparable to that reported from clinical trials and recent observational studies, supporting the effectiveness of mRNA COVID-19 vaccines against symptomatic disease in adults, with strong 2-dose protection.
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19 Testing[MESH]
  • |COVID-19 Vaccines/administration & dosage/*immunology[MESH]
  • |COVID-19/epidemiology/*prevention & control[MESH]
  • |Case-Control Studies[MESH]
  • |Female[MESH]
  • |Health Personnel/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Immunization Schedule[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Occupational Diseases/epidemiology/*prevention & control[MESH]
  • |United States/epidemiology[MESH]


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